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XL-228

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IGF-1R, Aurora, FGFR, ABL, SRC 抑制剂

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产品目录号: A13069

库存状态:中国现货中国现货

产品名 目录号 价格 数量
XL-228 5mg A13069-5
¥ 900.00
XL-228 10mg A13069-10
¥ 1,500.00
XL-228 25mg A13069-25
¥ 3,000.00
XL-228 50mg A13069-50
¥ 4,700.00

产品仅用于研究,不针对患者销售,望谅解.

产品简介

XL228 is a protein kinase inhibitor targeting IGF1R, the AURORA kinases, FGFR1-3, ABL and SRC family kinases. XL228 is an Aurora A inhibitor (IC50, f3 nmol/L) that has shown potent biochemical activity against ABL1 (Ki, 5 nmol/L), as well as the BCR-ABL1 T315I (Ki, 1.4 nmol/L) kinases.

XL-228

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Chemical Information

目录号 A13069
Mechanism of action Inhibitor
分子量 515.65
化学分子式 C28H37N9O
Solubility DMSO
纯度 >98%
储存方式 at -20°C 2 years
CAS No. 898280-07-4
Synonyms
SMILES code CC(C)C1=NOC(=C1)CNC2=NC(=CC(=N2)NC3=NNC(=C3)C4CC4)N5CCN(CC5)C
化学名称 N/A

生物活性

Description
XL228 is a protein kinase inhibitor targeting IGF1R, the AURORA kinases, FGFR1-3, ABL and SRC family kinases. XL228 is an Aurora A inhibitor (IC50, f3 nmol/L) that has shown potent biochemical activity against ABL1 (Ki, 5 nmol/L), as well as the BCR-ABL1 T315I (Ki, 1.4 nmol/L) kinases.

制备储备液

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 19.39 mL 96.96 mL 193.93mL
0.5 mM 3.88 mL 19.39 mL 38.79 mL
1 mM 1.94 mL 9.7 mL 19.39 mL
5 mM 0.39 mL 1.94 mL 3.88 mL

*The above data is based on the productmolecular weight 515.65. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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