XL-228

目录号: A13069

IGF-1R, Aurora, FGFR, ABL, SRC inhibitor

XL-228 Chemical Structure

CAS NO. 898280-07-4

XL228 is a protein kinase inhibitor targeting IGF1R, the AURORA kinases, FGFR1-3, ABL and SRC family kinases. XL228 is an Aurora A inhibitor (IC50, f3 nmol/L) that has shown potent biochemical activity against ABL1 (Ki, 5 nmol/L), as well as the BCR-ABL1 T315I (Ki, 1.4 nmol/L) kinases.

库存: 现货

规格 价格 数量
5 mg
¥ 900.00
10 mg
¥ 1,500.00
25 mg
¥ 3,000.00
50 mg
¥ 4,700.00
Warning 产品仅用于科学研究,不针对患者销售,望谅解.

详情

XL228 is a protein kinase inhibitor targeting IGF1R, the AURORA kinases, FGFR1-3, ABL and SRC family kinases. XL228 is an Aurora A inhibitor (IC50, f3 nmol/L) that has shown potent biochemical activity against ABL1 (Ki, 5 nmol/L), as well as the BCR-ABL1 T315I (Ki, 1.4 nmol/L) kinases.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 19.39 mL 96.96 mL 193.93 mL
0.5 mM 3.88 mL 19.39 mL 38.79 mL
1 mM 1.94 mL 9.7 mL 19.39 mL
5 mM 0.39 mL 1.94 mL 3.88 mL

*The above data is based on the productmolecular weight 515.65. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

目录号 A13069
MECHANISM OF ACTION Inhibitor
M. Wt 515.65
Formula C28H37N9O
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 898280-07-4
Synonyms
SMILES CC(C)C1=NOC(=C1)CNC2=NC(=CC(=N2)NC3=NNC(=C3)C4CC4)N5CCN(CC5)C

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