XL019

目录号: A12394

JAK2 抑制剂

XL019 Chemical Structure

CAS NO. 945755-56-6

XL019是janus相关激酶2 (JAK-2)的生物可利用抑制剂,具有潜在的抗肿瘤活性。

库存: 现货

规格 价格 数量
5 mg
¥ 900.00
10 mg
¥ 1,500.00
25 mg
¥ 2,500.00
100 mg
¥ 7,500.00
10mM * 1mL in DMSO
¥ 1,390.00
Warning 产品仅用于科学研究,不针对患者销售,望谅解.

产品详情

XL019是janus相关激酶2 (JAK-2)的生物可利用抑制剂,具有潜在的抗肿瘤活性。
Targets
Target Value
JAK2IC50: 2.2nM
PDGFRβIC50: 125.4nM
JAK1IC50: 134.3nM
FLT3IC50: 139.7nM
JAK3IC50: 214.2nM
c-KitIC50: 225.8nM
p70S6KIC50: 313.8nM
TYK2IC50: 348.3nM
MLK1IC50: 370.0nM
IKKβIC50: 375.4nM
KDRIC50: 483.6nM
PDGFRαIC50: 546.7nM
FLT4IC50: 554.5nM
FLT1IC50: 910.5nM
In vitro DMSO 16 mg/mL (35.99 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 22.5 mL 112.48 mL 224.96 mL
0.5 mM 4.5 mL 22.5 mL 44.99 mL
1 mM 2.25 mL 11.25 mL 22.5 mL
5 mM 0.45 mL 2.25 mL 4.5 mL

*The above data is based on the productmolecular weight 444.53. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

目录号 A12394
MECHANISM OF ACTION Inhibitor
M. Wt 444.53
Formula C25H28N6O2
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 945755-56-6
Synonyms XL 019, XL-019
SMILES C1C[C@H](NC1)C(=O)NC2=CC=C(C=C2)C3=NC(=NC=C3)NC4=CC=C(C=C4)N5CCOCC5

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