XL147 analogue

目录号: A10995

PI3K Inhibitor

XL147 analogue Chemical Structure

CAS NO. 956958-53-5

XL147 is a potent, selective and orally bioavailable small molecule inhibitor of class I phosphatidylinositol 3 kinase (PI3K) with potential antineoplastic activity.

库存: 现货

规格 价格 数量
10 mg
¥ 1,000.00
25 mg
¥ 2,000.00
50 mg
¥ 2,800.00
100 mg
¥ 4,800.00
Warning 产品仅用于科学研究,不针对患者销售,望谅解.

产品详情

XL147 is a potent, selective and orally bioavailable small molecule inhibitor of class I phosphatidylinositol 3 kinase (PI3K) with potential antineoplastic activity.
Targets
Target Value
PI3KγIC50: 23nM
PI3KδIC50: 36nM
PI3KαIC50: 39nM
PI3KβIC50: 383nM
DNA-PKIC50: 4.75μM
Vps34IC50: 6.975μM
MEKIC50: >10μM
B-Raf/C-RafIC50: >10μM
mTORIC50: >15μM
In vitro (25°C) DMSO 3 mg/mL (6.68 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 30% PEG400/0.5% Tween80/5% propylene glycol 15 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 22.3 mL 111.48 mL 222.97 mL
0.5 mM 4.46 mL 22.3 mL 44.59 mL
1 mM 2.23 mL 11.15 mL 22.3 mL
5 mM 0.45 mL 2.23 mL 4.46 mL

*The above data is based on the productmolecular weight 448.5 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

目录号 A10995
MECHANISM OF ACTION Inhibitor
M. Wt 448.5
Formula C21H16N6O2S2
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 956958-53-5
Synonyms XL-147, SAR245408
SMILES CC1=CC=C(C=C1)S(=O)(=O)NC2=NC3=CC=CC=C3N=C2NC4=CC5=NSN=C5C=C4

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