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XL388

促销

mTOR 抑制剂

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产品目录号: A12395

库存状态:中国现货中国现货

产品名 目录号 价格 数量
XL388 5mg A12395-5
¥ 1,500.00
XL388 10mg A12395-10
¥ 2,500.00
XL388 25mg A12395-25
¥ 5,000.00
XL388 100mg A12395-100
¥ 10,000.00
XL388 10mM * 1mL in DMSO A12395-10mM-D
¥ 2,590.00

产品仅用于研究,不针对患者销售,望谅解.

产品简介

XL388 is a Novel Class of Highly Potent, Selective, ATP-Competitive, and Orally Bioavailable Inhibitors of the Mammalian Target of Rapamycin (mTOR).

XL388

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Chemical Information

目录号 A12395
Mechanism of action Inhibitor
分子量 455.5
化学分子式 C23H22FN3O4S
Solubility DMSO
纯度 >98%
储存方式 at -20°C 2 years
CAS No. 1251156-08-7
Synonyms XL 388, XL-388
SMILES code CC1=C(C=CC(=C1F)S(=O)(=O)C)C(=O)N2CCOC3=C(C2)C=C(C=C3)C4=CN=C(C=C4)N
化学名称 (7-(6-aminopyridin-3-yl)-2,3-dihydrobenzo[f][1,4]oxazepin-4(5H)-yl)(3-fluoro-2-methyl-4-(methylsulfonyl)phenyl)methanone

生物活性

Description
XL388 is a Novel Class of Highly Potent, Selective, ATP-Competitive, and Orally Bioavailable Inhibitors of the Mammalian Target of Rapamycin (mTOR).
Targets
Target Value
mTORC1IC50: 8nM
mTORIC50: 9.9nM
mTORC2IC50: 166nM
PI3KαIC50: >3μM
CYP2C9IC50: 10.6μM
CYP2C8IC50: >20μM
CYP2D6IC50: >20μM
CYP3A4IC50: 24.6μM

溶解性

Solubility (25°C) * In vitro DMSO 23 mg/mL (50.49 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 30% PEG400/0.5% Tween80/5% propylene glycol 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 21.95 mL 109.77 mL 219.54mL
0.5 mM 4.39 mL 21.95 mL 43.91 mL
1 mM 2.2 mL 10.98 mL 21.95 mL
5 mM 0.44 mL 2.2 mL 4.39 mL

*The above data is based on the productmolecular weight 455.5. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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