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mTOR 抑制剂

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产品目录号: A12395


产品名 目录号 价格 数量
XL388 5mg A12395-5
¥ 1,500.00
XL388 10mg A12395-10
¥ 2,500.00
XL388 25mg A12395-25
¥ 5,000.00
XL388 100mg A12395-100
¥ 10,000.00
XL388 10mM * 1mL in DMSO A12395-10mM-D
¥ 2,590.00



XL388 is a Novel Class of Highly Potent, Selective, ATP-Competitive, and Orally Bioavailable Inhibitors of the Mammalian Target of Rapamycin (mTOR).





顾客使用 Adooq 产品发表的高质量科研文献

Chemical Information

目录号 A12395
Mechanism of action Inhibitor
分子量 455.5
化学分子式 C23H22FN3O4S
Solubility DMSO
纯度 >98%
储存方式 at -20°C 2 years
CAS No. 1251156-08-7
Synonyms XL 388, XL-388
SMILES code CC1=C(C=CC(=C1F)S(=O)(=O)C)C(=O)N2CCOC3=C(C2)C=C(C=C3)C4=CN=C(C=C4)N
化学名称 (7-(6-aminopyridin-3-yl)-2,3-dihydrobenzo[f][1,4]oxazepin-4(5H)-yl)(3-fluoro-2-methyl-4-(methylsulfonyl)phenyl)methanone


XL388 is a Novel Class of Highly Potent, Selective, ATP-Competitive, and Orally Bioavailable Inhibitors of the Mammalian Target of Rapamycin (mTOR).
Target Value
mTORC1IC50: 8nM
mTORIC50: 9.9nM
mTORC2IC50: 166nM
PI3KαIC50: >3μM
CYP2C9IC50: 10.6μM
CYP2C8IC50: >20μM
CYP2D6IC50: >20μM
CYP3A4IC50: 24.6μM


Solubility (25°C) * In vitro DMSO 23 mg/mL (50.49 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 30% PEG400/0.5% Tween80/5% propylene glycol 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.


Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 21.95 mL 109.77 mL 219.54mL
0.5 mM 4.39 mL 21.95 mL 43.91 mL
1 mM 2.2 mL 10.98 mL 21.95 mL
5 mM 0.44 mL 2.2 mL 4.39 mL

*The above data is based on the productmolecular weight 455.5. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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