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XL765

促销

PI3K 抑制剂

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产品目录号: A10997

库存状态:中国现货中国现货

产品名 目录号 价格 数量
XL765 5mg A10997-5
¥ 900.00
XL765 10mg A10997-10
¥ 1,600.00
XL765 50mg A10997-50
¥ 4,500.00
XL765 100mg A10997-100
¥ 7,500.00
XL765 10mM * 1mL in DMSO A10997-10mM-D
¥ 1,670.00

产品仅用于研究,不针对患者销售,望谅解.

产品简介

XL765 is a PI3K/mTOR dual kinase inhibitor and it is more potent compared to an agent that inhibits either PI3K kinase or mTOR kinase alone.

XL765

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Chemical Information

目录号 A10997
Mechanism of action Inhibitor
分子量 599.7
化学分子式 C31H29N5O6S
Solubility DMSO
纯度 >98%
储存方式 at -20°C 2 years
CAS No. 1349796-36-6
Synonyms XL-765
SMILES code CC1=C(C=C(C=C1)C(=O)NC2=CC=C(C=C2)S(=O)(=O)NC3=NC4=CC=CC=C4N=C3NC5=CC(=CC(=C5)OC)OC)OC
化学名称 N-[2-[(3,5-Dimethoxyphenyl)amino]quinoxalin-3-yl]-4-[(4-methyl-3-methoxyphenyl)carbonyl]aminophenylsulfonamide

生物活性

Description
XL765 is a PI3K/mTOR dual kinase inhibitor and it is more potent compared to an agent that inhibits either PI3K kinase or mTOR kinase alone.
Targets
Target Value
PI3KγIC50: 9nM
PI3KαIC50: 39nM
PI3KδIC50: 43nM
PI3KβIC50: 113nM
DNA-PKIC50: 150nM
mTORIC50: 157nM

溶解性

Solubility (25°C) * In vitro DMSO 12 mg/mL (20.01 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 30% PEG400/0.5% Tween80/5% propylene glycol 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 16.68 mL 83.38 mL 166.75mL
0.5 mM 3.34 mL 16.68 mL 33.35 mL
1 mM 1.67 mL 8.34 mL 16.68 mL
5 mM 0.33 mL 1.67 mL 3.34 mL

*The above data is based on the productmolecular weight 599.7 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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