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PI3K 抑制剂

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产品目录号: A10997


产品名 目录号 价格 数量
XL765 5mg A10997-5
¥ 900.00
XL765 10mg A10997-10
¥ 1,600.00
XL765 50mg A10997-50
¥ 4,500.00
XL765 100mg A10997-100
¥ 7,500.00
XL765 10mM * 1mL in DMSO A10997-10mM-D
¥ 1,670.00



XL765 is a PI3K/mTOR dual kinase inhibitor and it is more potent compared to an agent that inhibits either PI3K kinase or mTOR kinase alone.





顾客使用 Adooq 产品发表的高质量科研文献

Chemical Information

目录号 A10997
Mechanism of action Inhibitor
分子量 599.7
化学分子式 C31H29N5O6S
Solubility DMSO
纯度 >98%
储存方式 at -20°C 2 years
CAS No. 1349796-36-6
Synonyms XL-765
SMILES code CC1=C(C=C(C=C1)C(=O)NC2=CC=C(C=C2)S(=O)(=O)NC3=NC4=CC=CC=C4N=C3NC5=CC(=CC(=C5)OC)OC)OC
化学名称 N-[2-[(3,5-Dimethoxyphenyl)amino]quinoxalin-3-yl]-4-[(4-methyl-3-methoxyphenyl)carbonyl]aminophenylsulfonamide


XL765 is a PI3K/mTOR dual kinase inhibitor and it is more potent compared to an agent that inhibits either PI3K kinase or mTOR kinase alone.
Target Value
PI3KγIC50: 9nM
PI3KαIC50: 39nM
PI3KδIC50: 43nM
PI3KβIC50: 113nM
DNA-PKIC50: 150nM
mTORIC50: 157nM


Solubility (25°C) * In vitro DMSO 12 mg/mL (20.01 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 30% PEG400/0.5% Tween80/5% propylene glycol 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.


Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 16.68 mL 83.38 mL 166.75mL
0.5 mM 3.34 mL 16.68 mL 33.35 mL
1 mM 1.67 mL 8.34 mL 16.68 mL
5 mM 0.33 mL 1.67 mL 3.34 mL

*The above data is based on the productmolecular weight 599.7 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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