XmAb 5592 is a humanized, Fc-engineered monoclonal antibody targeting HM1.24, designed to enhance binding affinity to Fc??RIIIa and Fc??RIIa receptors. This antibody facilitates increased lysis of HM1.24-specific multiple myeloma (MM) cells through both antibody-dependent cellular cytotoxicity (ADCC) and antibody-dependent cellular phagocytosis (ADCP) in vitro. This specificity and mechanism of action make XmAb 5592 a valuable tool for research into therapeutic interventions for multiple myeloma.
XmAb 5592 is a humanized, Fc-engineered monoclonal antibody targeting HM1.24, designed to enhance binding affinity to Fc??RIIIa and Fc??RIIa receptors. This antibody facilitates increased lysis of HM1.24-specific multiple myeloma (MM) cells through both antibody-dependent cellular cytotoxicity (ADCC) and antibody-dependent cellular phagocytosis (ADCP) in vitro. This specificity and mechanism of action make XmAb 5592 a valuable tool for research into therapeutic interventions for multiple myeloma.
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