YF-2
目录号: A21018
histone acetyltransferase activator
YF-2 是一种高度选择性的、能穿透血脑屏障的组蛋白乙酰转移酶激活剂，能在海马区乙酰化H3，对CBP、PCAF和GCN5的EC50分别为2.75微米、29.04微米和49.31微米，对HDAC无影响。具有抗癌和抗阿尔茨海默病的作用。
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生物活性
| Discription | YF-2 is a highly selective, blood-brain-barrier permeable histone acetyltransferase activator, acetylates H3 in the hippocampus, with EC50s of 2.75 μM, 29.04 μM and 49.31 μM for CBP, PCAF, and GCN5, respectively, shows no effect on HDAC. Anti-cancer and anti-Alzheimer's disease. | ||
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产品信息
| 目录号 | A21018 |
|---|---|
| 分子式 | C20H22ClF3N2O3 |
| 分子量 | 430.85 |
| CAS号 | 1311423-89-8 |
| SMILES | O=C(NC1=CC=C(Cl)C(C(F)(F)F)=C1)C2=C(OCC)C=CC=C2OCCN(C)C |
| 其他名称 | YF2, YF 2 |
| 储存条件 | Store lyophilized at -20ºC, keep desiccated. |
溶解性数据
| In vitro | DMSO | 78 mg/mL (181.03 mM) | |
| Water | 78 mg/mL (181.03 mM) | ||
| Ethanol | 78 mg/mL (181.03 mM) | ||
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* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
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Preparing Stock Solutions
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 23.21 mL | 116.05 mL | 232.1 mL |
| 0.5 mM | 4.64 mL | 23.21 mL | 46.42 mL |
| 1 mM | 2.32 mL | 11.6 mL | 23.21 mL |
| 5 mM | 0.46 mL | 2.32 mL | 4.64 mL |
Useful Calculator
Calculate the dilution required to prepare a stock solution. This equation is commonly abbreviated as: C1V1 = C2V2
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| 购买 1311423-89-8 | 1311423-89-8 供应商 | 1311423-89-8 花费 | 1311423-89-8 生产商 | 订购 1311423-89-8 | 1311423-89-8 代理商