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YM-90709是白介素5受体拮抗剂。YM-90709抑制IL-5与其周围人嗜酸性粒细胞和丁酸处理的嗜酸性HL-60克隆15细胞的受体结合，IC50值分别为1.0和0.57 microM。
| In vitro | DMSO | 42 mg/mL (116.85 mM) | |
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
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| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 27.82 mL | 139.11 mL | 278.22 mL |
| 0.5 mM | 5.56 mL | 27.82 mL | 55.64 mL |
| 1 mM | 2.78 mL | 13.91 mL | 27.82 mL |
| 5 mM | 0.56 mL | 2.78 mL | 5.56 mL |
*The above data is based on the productmolecular weight 359.43. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A15999 |
|---|---|
| 作用机制 | Antagonist (拮抗剂) |
| M. Wt | 359.43 |
| Formula | C22H21N3O2 |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 163769-88-8 |
| Synonyms | YM 90709, YM90709 |
| SMILES | CC(CC1=CC(OC)=C(OC)C=C12)(C)N3C2=CC4=NC5=CC=CC=C5N=C43 |
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