Zalutumumab is a fully human IgG1 monoclonal antibody exhibiting high affinity for the epidermal growth factor receptor (EGFR). It specifically binds to domain III of EGFR, effectively blocking the receptor's interaction with its natural ligand, EGF. This interaction inhibits the receptor's activation by steric hindrance, preventing its transition to an active conformation. Zalutumumab demonstrates binding affinities with half-maximal effective concentrations (EC50) of 7 nM for the whole IgG and 19 nM for its Fab fragment. This antibody is primarily utilized in cancer research, providing a valuable tool for investigating EGFR's role in oncogenic processes and therapeutic interventions.
Zalutumumab is a fully human IgG1 monoclonal antibody exhibiting high affinity for the epidermal growth factor receptor (EGFR). It specifically binds to domain III of EGFR, effectively blocking the receptor's interaction with its natural ligand, EGF. This interaction inhibits the receptor's activation by steric hindrance, preventing its transition to an active conformation. Zalutumumab demonstrates binding affinities with half-maximal effective concentrations (EC50) of 7 nM for the whole IgG and 19 nM for its Fab fragment. This antibody is primarily utilized in cancer research, providing a valuable tool for investigating EGFR's role in oncogenic processes and therapeutic interventions.
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