ZCL-278
目录号: A13403
Cdc42 GTPase 抑制剂
ZCL-278 是一种选择性的 Cdc42 抑制剂。它针对 Cdc42 鸟嘌呤核苷酸交换因子，交叉蛋白（ITSN）的结合位点。抑制 Cdc42 介导的细胞效应，包括在3T3成纤维细胞中的微刺形成和在初生新生皮层神经元中的神经分支形成。同时，它还抑制了PC3细胞的细胞运动和迁移，且没有细胞性毒作用。
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生物活性
| Discription | ZCL-278 is a selective inhibitor of Cdc42. Targets the binding site of the Cdc42 guanine nucleotide exchange factor, intersectin (ITSN). Inhibits Cdc42-mediated cellular effects, including microspike formation in 3T3 fibroblasts and neuronal branching in primary neonatal cortical neurons. Also suppresses cell motility and migration in PC3 cells, without cytotoxic effects. | ||
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产品信息
| 目录号 | A13403 |
|---|---|
| 分子式 | C21H19BrClN5O4S2 |
| 分子量 | 584.89 |
| CAS号 | 587841-73-4 |
| SMILES | CC1=CC(=NC(=N1)NS(=O)(=O)C2=CC=C(C=C2)NC(=S)NC(=O)COC3=C(C=C(C=C3)Br)Cl)C |
| 其他名称 | ZCL278, ZCL 278 |
| 储存条件 | Store lyophilized at -20ºC, keep desiccated. |
溶解性数据
| In vitro | DMSO | 99 mg/mL (169.26 mM) | |
| Water | Insoluble | ||
| Ethanol | Insoluble | ||
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* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
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Preparing Stock Solutions
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 17.1 mL | 85.49 mL | 170.97 mL |
| 0.5 mM | 3.42 mL | 17.1 mL | 34.19 mL |
| 1 mM | 1.71 mL | 8.55 mL | 17.1 mL |
| 5 mM | 0.34 mL | 1.71 mL | 3.42 mL |
Useful Calculator
Calculate the dilution required to prepare a stock solution. This equation is commonly abbreviated as: C1V1 = C2V2
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| 购买 587841-73-4 | 587841-73-4 供应商 | 587841-73-4 花费 | 587841-73-4 生产商 | 订购 587841-73-4 | 587841-73-4 代理商