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Zibotentan (ZD4054)

ETA-receptor 拮抗剂

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产品目录号: A11006

库存状态:中国现货中国现货

产品名 目录号 价格 数量
Zibotentan 5mg A11006-5
¥ 900.00
Zibotentan 10mg A11006-10
¥ 1,600.00
Zibotentan 50mg A11006-50
¥ 4,500.00
Zibotentan 100mg A11006-100
¥ 7,500.00
Zibotentan (ZD4054) 10mM * 1mL in DMSO A11006-10mM-D
¥ 1,350.00

产品仅用于研究,不针对患者销售,望谅解.

产品简介

Zibotentan (ZD4054)is an orally administered, potent and specific ETA-receptor (endothelin A receptor) antagonist (IC50 = 21 nM).

Zibotentan (ZD4054)

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顾客使用 Adooq 产品发表的高质量科研文献
Adooq 顾客使用 Zibotentan (ZD4054) 发表的文献 (1)
  • Tony Ngo, .et al. Orphan receptor ligand discovery by pickpocketing pharmacological neighbors, Nat Chem Biol, 2017, Feb; 13(2): 235每242 PMID: 27992882

Chemical Information

目录号 A11006
Mechanism of action Antagonist
分子量 424.4
化学分子式 C19H16N6O4S
Solubility DMSO
纯度 >98%
储存方式 at -20°C 2 years
CAS No. 186497-07-4
Synonyms ZD-4054
SMILES code CC1=CN=C(C(=N1)OC)NS(=O)(=O)C2=C(N=CC=C2)C3=CC=C(C=C3)C4=NN=CO4
化学名称 N-(3-Methoxy-5-methyl-2-pyrazinyl)-2-[4-(1,3,4-oxadiazol-2-yl)phenyl]-3-pyridinesulfonamide

生物活性

Description
Zibotentan (ZD4054)is an orally administered, potent and specific ETA-receptor (endothelin A receptor) antagonist (IC50 = 21 nM).
Targets
ET-A
21 nM

溶解性

Solubility (25°C) * In vitro DMSO 24 mg/mL (56.54 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 1% DMSO/30% polyethylene glycol/1% Tween 80 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 23.56 mL 117.81 mL 235.63mL
0.5 mM 4.71 mL 23.56 mL 47.13 mL
1 mM 2.36 mL 11.78 mL 23.56 mL
5 mM 0.47 mL 2.36 mL 4.71 mL

*The above data is based on the productmolecular weight 424.4 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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