Zibotentan (ZD4054)

Name: Zibotentan (ZD4054)
SKU: A11006

目录号: A11006

ETA-receptor 拮抗剂

Product Citations (1)

Zibotentan (ZD4054) Chemical Structure

CAS NO. 186497-07-4

Zibotentan (ZD4054)是一种有效且特异性的ETA受体（内皮素A受体）拮抗剂（IC50 = 21 nM），对ETB没有抑制活性。

库存：现货

规格	价格	数量
5 mg	￥ 900.00
10 mg	￥ 1,600.00
50 mg	￥ 4,500.00
100 mg	￥ 7,500.00
10mM * 1mL in DMSO	￥ 1,350.00

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生物活性

Zibotentan (ZD4054)是一种有效且特异性的ETA受体（内皮素A受体）拮抗剂（IC50 = 21 nM），对ETB没有抑制活性。

靶点信息

ET-A
21 nM

溶解度 *

In vitro (25°C)	DMSO	23 mg/mL (54.18 mM)
	Water	Insoluble
	Ethanol	Insoluble
In vivo	1% DMSO+30% polyethylene glycol+1% Tween 80	28 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	23.56 mL	117.81 mL	235.63 mL
0.5 mM	4.71 mL	23.56 mL	47.13 mL
1 mM	2.36 mL	11.78 mL	23.56 mL
5 mM	0.47 mL	2.36 mL	4.71 mL

*The above data is based on the productmolecular weight 424.4 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

化学数据

目录号	A11006
作用机制	Antagonist (拮抗剂)
M. Wt	424.4
Formula	C19H16N6O4S
Purity	>99%
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
CAS No.	186497-07-4
Synonyms	ZD-4054
SMILES	CC1=CN=C(C(=N1)OC)NS(=O)(=O)C2=C(N=CC=C2)C3=CC=C(C=C3)C4=NN=CO4