ZM-447439

目录号: A11009

Aurora Kinase inhibitor

ZM-447439 Chemical Structure

CAS NO. 331771-20-1

ZM 447439 is a selective and ATP-competitive inhibitor for Aurora A and Aurora B with IC50 of 110 nM and 130 nM, respectively. It is more than 8-fold selective for Aurora A/B than MEK1, Src, Lck and has little effect against CDK1/2/4, Plk1, Chk1, etc.

库存: 现货

规格 价格 数量
5 mg
¥ 400.00
10 mg
¥ 700.00
25 mg
¥ 1,500.00
50 mg
¥ 2,600.00
10mM * 1mL in DMSO
¥ 1,000.00
Warning 产品仅用于科学研究,不针对患者销售,望谅解.

详情

ZM 447439 is a selective and ATP-competitive inhibitor for Aurora A and Aurora B with IC50 of 110 nM and 130 nM, respectively. It is more than 8-fold selective for Aurora A/B than MEK1, Src, Lck and has little effect against CDK1/2/4, Plk1, Chk1, etc.
Targets
Target Value
AuroraAIC50: 110nM
AuroraBIC50: 130nM
LCKIC50: 880nM
SrcIC50: 1.03μM
MEK1IC50: 1.79μM
CDK1IC50: >10μM
CDK2IC50: >10μM
CDK4IC50: >10μM
PLK1IC50: >10μM
Chk1IC50: >10μM
IKK1IC50: >10μM
IKK2IC50: >10μM
cFLT2IC50: >10μM
KDR2IC50: >10μM
ZAP70IC50: >10μM
FAKIC50: >10μM
In vitro (25°C) DMSO 103 mg/mL (200.54 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 30% PEG400/0.5% Tween80/5% propylene glycol 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 19.47 mL 97.35 mL 194.7 mL
0.5 mM 3.89 mL 19.47 mL 38.94 mL
1 mM 1.95 mL 9.74 mL 19.47 mL
5 mM 0.39 mL 1.95 mL 3.89 mL

*The above data is based on the productmolecular weight 513.6 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

目录号 A11009
MECHANISM OF ACTION Inhibitor
M. Wt 513.6
Formula C29H31N5O4
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 331771-20-1
Synonyms ZM447439
SMILES COC1=C(C=C2C(=C1)C(=NC=N2)NC3=CC=C(C=C3)NC(=O)C4=CC=CC=C4)OCCCN5CCOCC5

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