AFP464 is a prodrug of Aminoflavone and an agonist of the aryl hydrocarbon receptor (AhR). It exhibits significant biological activity by downregulating α6-integrin expression, inhibiting breast tumor growth, and reducing the population of tumor-initiating cells. Additionally, AFP464 disrupts mammosphere structure, induces mucin lake cluster formation, triggers DNA damage, and demonstrates antiproliferative effects. This compound is suitable for research applications focused on breast cancer.
AFP464 is a prodrug of Aminoflavone and an agonist of the aryl hydrocarbon receptor (AhR). It exhibits significant biological activity by downregulating α6-integrin expression, inhibiting breast tumor growth, and reducing the population of tumor-initiating cells. Additionally, AFP464 disrupts mammosphere structure, induces mucin lake cluster formation, triggers DNA damage, and demonstrates antiproliferative effects. This compound is suitable for research applications focused on breast cancer.
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