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Alectinib Hydrochloride

Alectinib Hydrochloride

Name: Alectinib Hydrochloride
SKU: A18000

目录号: A18000

ALK inhibitor

Alectinib Hydrochloride Chemical Structure

CAS NO. 1256589-74-8

Alectinib Hydrochloride (CH5424802 Hydrochloride; RO5424802 Hydrochloride; AF-802 Hydrochloride) is a potent, selective, and orally available ALK inhibitor with an IC50 of 1.9 nM and a Kd value of 2.4 nM (in an ATP-competitive manner), and also inhibits ALK F1174L and ALK R1275Q with IC50s of 1 nM and 3.5 nM, respectively.

库存：现货

规格	价格	数量
5 mg	￥ 650.00
10 mg	￥ 1,120.00
50 mg	￥ 3,310.00
100 mg	￥ 6,620.00

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产品详情

生物活性

溶解度 *

In vitro	DMSO	2 mg/mL (3.85 mM)
	Water	Insoluble
	Ethanol	Insoluble
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	19.26 mL	96.32 mL	192.65 mL
0.5 mM	3.85 mL	19.26 mL	38.53 mL
1 mM	1.93 mL	9.63 mL	19.26 mL
5 mM	0.39 mL	1.93 mL	3.85 mL

*The above data is based on the productmolecular weight 519.08. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

化学数据

目录号	A18000
作用机制	Inhibitor (抑制剂)
M. Wt	519.08
Formula	C30H35ClN4O2
Purity	>99%
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
CAS No.	1256589-74-8
Synonyms	CH5424802 Hydrochloride, CH 5424802, CH-5424802; RO5424802 Hydrochloride, RO 5424802, RO-5424802; AF-802 Hydrochloride,
SMILES	[H]Cl.N#CC1=CC2=C(C3=C(N2)C(C)(C4=CC(N5CCC(CC5)N6CCOCC6)=C(C=C4C3=O)CC)C)C=C1