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AZD1152-HQPA (Barasertib)


Aurora Kinase B 抑制剂

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产品目录号: A10109


产品名 目录号 价格 数量
AZD1152-HQPA 5mg A10109-5
¥ 800.00
AZD1152-HQPA 10mg A10109-10
¥ 1,200.00
AZD1152-HQPA 50mg A10109-50
¥ 3,900.00
AZD1152-HQPA 100mg A10109-100
¥ 6,800.00
AZD1152-HQPA (Barasertib) 10mM * 1mL in DMSO A10109-10mM-D
¥ 1,400.00



AZD 1152-HQPA is a highly potent and selective inhibitor of Aurora B, with Ki values to be 0.36 (Aurora B) and 1369 nM (Aurora A) respectively and has a high specificity versus a panel of 50 other kinases.

AZD1152-HQPA (Barasertib)




顾客使用 Adooq 产品发表的高质量科研文献
Adooq 顾客使用 AZD1152-HQPA (Barasertib) 发表的文献 (2)
  • Sakamoto K, .et al. Recurrent 8q24 rearrangement in blastic plasmacytoid dendritic cell neoplasm: association with immunoblastoid cytomorphology, MYC expression, and drug response, Leukemia, 2018, May 23 PMID: 29795241
  • Jennifer M. Sahni, .et al. Bromodomain and Extraterminal Protein Inhibition Blocks Growth of Triple-negative Breast Cancers through the Suppression of Aurora Kinases, J Biol Chem, 2016, Nov 4; 291(45): 23756每23768 PMID: 27650498

Chemical Information

目录号 A10109
Mechanism of action Inhibitor
分子量 507.7
化学分子式 C26H30FN7O3
Solubility DMSO
纯度 >98%
储存方式 at -20°C 2 years
CAS No. 722544-51-6
Synonyms Barasertib
化学名称 5-[[7-[3-[Ethyl(2-hydroxyethyl)amino]propoxy]-4-quinazolinyl]amino]-N-(3-fluorophenyl)-1H-pyrazole-3-acetamide


AZD 1152-HQPA is a highly potent and selective inhibitor of Aurora B, with Ki values to be 0.36 (Aurora B) and 1369 nM (Aurora A) respectively and has a high specificity versus a panel of 50 other kinases.
Aurora B (Cell-free assay) Aurora A (Cell-free assay)
0.37 nM1368 nM


Solubility (25°C) * In vitro DMSO 102 mg/mL (200.96 mM)
Water <1 mg/mL (<1 mM)
Ethanol 3 mg/mL (5.91 mM)
In vivo 30% PEG400/0.5% Tween80/5% propylene glycol 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.


Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 19.7 mL 98.48 mL 196.97mL
0.5 mM 3.94 mL 19.7 mL 39.39 mL
1 mM 1.97 mL 9.85 mL 19.7 mL
5 mM 0.39 mL 1.97 mL 3.94 mL

*The above data is based on the productmolecular weight 507.7 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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