Infigratinib (BGJ398)

Name: Infigratinib (BGJ398)
SKU: A11159
Price: 210 CNY
Rating: 5 (4 reviews)

目录号: A11159

FGFR 抑制剂

4 篇发表文献

BGJ398 是一种强效且选择性的抑制剂，具有潜在的抗血管生成和抗肿瘤活性，针对成纤维细胞生长因子受体（FGFR）酪氨酸激酶1、2、3和4（分别对FGFR1、FGFR2、FGFR3和FGFR4的IC50值为0.9、1.4、1.0和60 nM）。

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Grouped product items
规格	价格	库存
5mg	¥210.00	现货
10mg	¥350.00	现货
25mg	¥525.00	现货
50mg	¥630.00	现货
100mg	¥1,050.00	现货
200mg	¥1,960.00	现货
500mg	¥3,360.00	现货
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重要通知：仅供研究使用。我们不向患者销售。

Data Sheet

SDS

Other Forms of Infigratinib (BGJ398)

NVP-BGJ398 phosphate

顾客使用 Adooq 产品发表的高质量科研文献

Adooq用户使用Infigratinib (BGJ398)发表的4篇文献

Takehito Yamamoto, .et al. , Cancers (Basel), 2020, Jul 22;12(8):E2010 PMID: 32708005

Daniel Limonta, .et al. , J Infect Dis, 2019, 2019 PMID: 30799482

Li Li, .et al. , Leukemia Res, 2019, 78:12-20 PMID: 30660961

Anil Kumar, .et al. , Sci Rep, 2018, 8: 5477 PMID: 29615760

生物活性

Discription

BGJ398 is a potent and selective inhibitor with potential antiangiogenic and antineoplastic activities of fibroblast growth factor receptor (FGFR) tyrosine kinases 1, 2, 3 and 4 (with IC50 values of 0.9, 1.4, 1.0 and 60 nM for FGFR1, FGFR2, FGFR3, and FGFR4 respectively).

Targets

Target	Value

Cell Research

Cell Line	Type	Value	Description	References

产品信息

目录号	A11159
分子式	C26H31Cl2N7O3
分子量	560.48
CAS号	872511-34-7
SMILES	CCN1CCN(CC1)C2=CC=C(C=C2)NC3=CC(=NC=N3)N(C)C(=O)NC4=C(C(=CC(=C4Cl)OC)OC)Cl
其他名称	BGJ-398
储存条件	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

溶解性数据

In vitro (25°C)	DMSO	Warmed: 1 mg/mL (1.78 mM)
	Water	Insoluble
	Ethanol	Insoluble
In vivo	1%CMC-Na	28 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	17.84 mL	89.21 mL	178.42 mL
0.5 mM	3.57 mL	17.84 mL	35.68 mL
1 mM	1.78 mL	8.92 mL	17.84 mL
5 mM	0.36 mL	1.78 mL	3.57 mL

Useful Calculator

This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

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* Please check COA/MSDS for correct molecular weight.

Calculate the dilution required to prepare a stock solution.
This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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