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BGJ398 (NVP-BGJ398)

促销

FGFR 抑制剂

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产品目录号: A11159

库存状态:中国现货中国现货

产品名 目录号 价格 数量
BGJ398 (NVP-BGJ398) 5mg A11159-5
¥ 500.00
BGJ398 (NVP-BGJ398) 10mg A11159-10
¥ 700.00
BGJ398 (NVP-BGJ398) 50mg A11159-50
¥ 1,400.00
BGJ398 (NVP-BGJ398) 100mg A11159-100
¥ 2,400.00

产品仅用于研究,不针对患者销售,望谅解.

产品简介

BGJ398 is a potent and selective inhibitor with potential antiangiogenic and antineoplastic activities of fibroblast growth factor receptor (FGFR) tyrosine kinases 1, 2, 3 and 4 (with IC50 values of 0.9, 1.4, 1.0 and 60 nM for FGFR1, FGFR2, FGFR3, and FGFR4 respectively).

BGJ398 (NVP-BGJ398)

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顾客使用 Adooq 产品发表的高质量科研文献
Adooq 顾客使用 BGJ398 (NVP-BGJ398) 发表的文献 (3)
  • Daniel Limonta, .et al. Fibroblast growth factor 2 enhances Zika virus infection in human fetal brain, J Infect Dis, 2019, 2019 PMID: 30799482
  • Li Li, .et al. Evidence for activated Lck protein tyrosine kinase as the driver of proliferation in acute myeloid leukemia cell, CTV-1, Leukemia Res, 2019, 78:12-20 PMID: 30660961
  • Anil Kumar, .et al. Human Sertoli cells support high levels of Zika virus replication and persistence, Sci Rep, 2018, 8: 5477 PMID: 29615760

Chemical Information

目录号 A11159
Mechanism of action Inhibitor
分子量 560.48
化学分子式 C26H31Cl2N7O3
Solubility DMSO
纯度 >98%
储存方式 at -20°C 2 years
CAS No. 872511-34-7
Synonyms BGJ-398
SMILES code CCN1CCN(CC1)C2=CC=C(C=C2)NC3=CC(=NC=N3)N(C)C(=O)NC4=C(C(=CC(=C4Cl)OC)OC)Cl
化学名称 3-(2,6-dichloro-3,5-dimethoxyphenyl)-1-(6-((4-(4-ethylpiperazin-1-yl)phenyl)amino)pyrimidin-4-yl)-1-methylurea

生物活性

Description
BGJ398 is a potent and selective inhibitor with potential antiangiogenic and antineoplastic activities of fibroblast growth factor receptor (FGFR) tyrosine kinases 1, 2, 3 and 4 (with IC50 values of 0.9, 1.4, 1.0 and 60 nM for FGFR1, FGFR2, FGFR3, and FGFR4 respectively).
Targets
Target Value
FGFR1IC50: 0.9nM
FGFR3IC50: 1.0nM
FGFR2IC50: 1.4nM
FGFR3(K650E)IC50: 4.9nM
FGFR4IC50: 60nM
VEGFR2IC50: 0.18μM
LynIC50: 0.30μM
KitIC50: 0.75μM
YESIC50: 1.1μM
FynIC50: 1.9μM
AblIC50: 2.3μM
LCKIC50: 2.5μM

溶解性

Solubility (25°C) * In vitro DMSO 1 mg/mL heating (1.78 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 30% PEG400/0.5% Tween80/5% propylene glycol 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 17.84 mL 89.21 mL 178.42mL
0.5 mM 3.57 mL 17.84 mL 35.68 mL
1 mM 1.78 mL 8.92 mL 17.84 mL
5 mM 0.36 mL 1.78 mL 3.57 mL

*The above data is based on the productmolecular weight 560.48. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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