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BKM120 (NVP-BKM120, Buparlisib)

BKM120 (NVP-BKM120, Buparlisib)

Name: BKM120 (NVP-BKM120, Buparlisib)
SKU: A11016

目录号: A11016

PI3K 抑制剂?

Product Citations (11)

BKM120 (NVP-BKM120, Buparlisib) Chemical Structure

CAS NO. 944396-07-0

BKM120 (NVP-BKM120,Buparlisib)是生物可利用的口服泛I类磷脂酰肌醇3激酶（PI3K）激酶抑制剂，在无细胞试验中作用于p110α/β/δ/γ的。对VPS34，mTOR，DNAPK的作用效果下降，而对 PI4Kβ几乎没有活性。

库存：现货

规格	价格	数量
5 mg	￥ 600.00
10 mg	￥ 900.00
25 mg	￥ 1,000.00
50 mg	￥ 1,200.00
10mM * 1mL in DMSO	￥ 600.00

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产品详情

生物活性

Targets

Target	Value
p110α	IC50: 52nM
p110δ	IC50: 116nM
p110β	IC50: 166nM
p110γ	IC50: 262nM
Vps34	IC50: 2.4μM
mTOR	IC50: 4.6μM
DNA-PK	IC50: >5μM
PI4Kβ	IC50: >25μM

溶解度 *

In vitro (25°C)	DMSO	76 mg/mL (185.18 mM)
	Water	Insoluble
	Ethanol	2 mg/mL (4.87 mM)
In vivo	5% DMSO+30% PEG 300+ddH2O	14 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	24.37 mL	121.83 mL	243.66 mL
0.5 mM	4.87 mL	24.37 mL	48.73 mL
1 mM	2.44 mL	12.18 mL	24.37 mL
5 mM	0.49 mL	2.44 mL	4.87 mL

*The above data is based on the productmolecular weight 410.4 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

化学数据

目录号	A11016
作用机制	Inhibitor (抑制剂)
M. Wt	410.4
Formula	C18H21F3N6O2
Purity	>99%
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
CAS No.	944396-07-0
SMILES	C1COCCN1C2=NC(=NC(=C2)C3=CN=C(C=C3C(F)(F)F)N)N4CCOCC4