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BKM120 (NVP-BKM120, Buparlisib)

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PI3K 抑制剂?€?

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产品目录号: A11016

库存状态:中国现货中国现货

产品名 目录号 价格 数量
BKM120 5mg A11016-5
¥ 600.00
BKM120 10mg A11016-10
¥ 900.00
BKM120 25mg A11016-25
¥ 1,000.00
BKM120 50mg A11016-50
¥ 1,200.00
BKM120 (NVP-BKM120) 10mM * 1mL in DMSO A11016-10mM-D
¥ 600.00

产品仅用于研究,不针对患者销售,望谅解.

产品简介

BKM120 (NVP-BKM120) is a bioavailable specific oral pan-class I phosphatidylinositol 3-kinase (PI3K) kinase inhibitor.

BKM120 (NVP-BKM120, Buparlisib)

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顾客使用 Adooq 产品发表的高质量科研文献
Adooq 顾客使用 BKM120 (NVP-BKM120, Buparlisib) 发表的文献 (7)
  • Nachi Namatame, .et al. Antitumor profile of the PI3K inhibitor ZSTK474 in human sarcoma cell lines, Oncotarget, 2018, Oct 12; 9(80): 35141每35161 PMID: 30416685
  • Jin H. Song, .et al. Mechanisms Behind Resistance to PI3K Inhibitor Treatment Induced by the PIM Kinase, Mol Cancer Ther, 2018, Dec;17(12):2710-2721 PMID: 30190422
  • Saijo A, .et al. Bone marrow-derived fibrocytes promote stem cell-like properties of lung cancer cells, Cancer Lett, 2018, May 1;421:17-27 PMID: 29448000
  • Hirosumi Tamura, .et al. Evaluation of anticancer agents using patient-derived tumor organoids characteristically similar to source tissues, Oncol Rep, 2018, Aug; 40(2): 635每646 PMID: 29917168
  • Pridham KJ, .et al. PIK3CB/p110汕 is a selective survival factor for glioblastoma, Neuro Oncol, 2018, Mar 27;20(4):494-505 PMID: 29016844
  • Charles-Andr谷 Philip, .et al. Inhibition of PI3K-AKT-mTOR pathway sensitizes endometrial cancer cell lines to PARP inhibitors, BMC Cancer, 2017, 17: 638 PMID: 28886696
  • Rogers HA, .et al. PI3K pathway activation provides a novel therapeutic target for pediatric ependymoma and is an independent marker of progression-free survival., Clin Cancer Res., 2013, Dec 1;19(23):6450-60 PMID: 24077346

Chemical Information

目录号 A11016
Mechanism of action Inhibitor
分子量 410.4
化学分子式 C18H21F3N6O2
Solubility DMSO
纯度 >98%
储存方式 at -20°C 2 years
CAS No. 944396-07-0
Synonyms N/A
SMILES code C1COCCN1C2=NC(=NC(=C2)C3=CN=C(C=C3C(F)(F)F)N)N4CCOCC4
化学名称 5-[2,6-Di(4-morpholinyl)-4-pyrimidinyl]-4-(trifluoromethyl)-2-pyridinamine

生物活性

Description
BKM120 (NVP-BKM120) is a bioavailable specific oral pan-class I phosphatidylinositol 3-kinase (PI3K) kinase inhibitor.
Targets
Target Value
p110αIC50: 52nM
p110δIC50: 116nM
p110βIC50: 166nM
p110γIC50: 262nM
Vps34IC50: 2.4μM
mTORIC50: 4.6μM
DNA-PKIC50: >5μM
PI4KβIC50: >25μM

溶解性

Solubility (25°C) * In vitro DMSO 82 mg/mL (199.8 mM)
Water <1 mg/mL (<1 mM)
Ethanol 2 mg/mL (4.87 mM)
In vivo 0.5% CMC Na 6 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 24.37 mL 121.83 mL 243.66mL
0.5 mM 4.87 mL 24.37 mL 48.73 mL
1 mM 2.44 mL 12.18 mL 24.37 mL
5 mM 0.49 mL 2.44 mL 4.87 mL

*The above data is based on the productmolecular weight 410.4 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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