CP-690550 (Tofacitinib citrate)

目录号: A10241

JAK3 抑制剂

CP-690550 (Tofacitinib citrate) Chemical Structure

CAS NO. 540737-29-9

CP-690550 (Tofacitinib citrate)是口服的高选择性Janus激酶(JAK)酶抑制剂。

库存: 现货

规格 价格 数量
10 mg
¥ 400.00
50 mg
¥ 900.00
100 mg
¥ 1,200.00
10mM * 1mL in DMSO
¥ 600.00
Warning 产品仅用于科学研究,不针对患者销售,望谅解.

产品详情

CP-690550 (Tofacitinib citrate)是口服的高选择性Janus激酶(JAK)酶抑制剂。
Targets
Target Value
JAK3IC50: 1nM
JAK2IC50: 20nM
JAK1IC50: 112nM
ROCK2IC50: 3.4μM
LCKIC50: 3.87μM
IRKIC50: >10μM
CDK2IC50: >10μM
CDK5IC50: >10μM
EGFRIC50: >10μM
MAPK2/ERK2IC50: >10μM
JNK1/SAPK1cIC50: >10μM
SAPK2a/p38IC50: >10μM
SAPK2b/p38b2IC50: >10μM
SAPK3/p38gIC50: >10μM
SAPK4/p38dIC50: >10μM
MAPKAPK2IC50: >10μM
MAPKAP-K1bIC50: >10μM
MSK1IC50: >10μM
PRAKIC50: >10μM
PKAIC50: >10μM
PKCαIC50: >10μM
PDK-1IC50: >10μM
PKBαIC50: >10μM
SGKIC50: >10μM
p70S6KIC50: >10μM
GSK-3βIC50: >10μM
AMPKIC50: >10μM
Chk1IC50: >10μM
CK2IC50: >10μM
PHKIC50: >10μM
CSKIC50: >10μM
CDK2/CyclinAIC50: >10μM
PI3KIC50: >10μM
In vitro (25°C) DMSO 100 mg/mL (198.21 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 0.5% methylcellulose 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 19.82 mL 99.11 mL 198.22 mL
0.5 mM 3.96 mL 19.82 mL 39.64 mL
1 mM 1.98 mL 9.91 mL 19.82 mL
5 mM 0.4 mL 1.98 mL 3.96 mL

*The above data is based on the productmolecular weight 504.5 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

目录号 A10241
MECHANISM OF ACTION Inhibitor
M. Wt 504.5
Formula C16H20N6O.C6H8O7
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 540737-29-9
Synonyms CP690550, tasocitinib citrate, CP-690,550
SMILES C[C@@H]1CCN(C[C@@H]1N(C)C2=NC=NC3=C2C=CN3)C(=O)CC#N.C(C(=O)O)C(CC(=O)O)(C(=O)O)O

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