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CP-690550 (Tofacitinib citrate)

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JAK3 抑制剂

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产品目录号: A10241

库存状态:中国现货中国现货

产品名 目录号 价格 数量
CP-690550 10mg A10241-10
¥ 600.00
CP-690550 50mg A10241-50
¥ 2,200.00
CP-690550 100mg A10241-100
¥ 3,800.00
CP-690550 10mM * 1mL in DMSO A10241-10mM-D
¥ 890.00

产品仅用于研究,不针对患者销售,望谅解.

产品简介

CP-690550 (Tofacitinib citrate) is an orally available, highly selective inhibitor of the Janus kinase (JAK) family of enzymes.

CP-690550 (Tofacitinib citrate)

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顾客使用 Adooq 产品发表的高质量科研文献
Adooq 顾客使用 CP-690550 (Tofacitinib citrate) 发表的文献 (1)
  • Fujita KI, .et al. Involvement of the Transporters P-Glycoprotein and Breast Cancer Resistance Protein in Dermal Distribution of the Multikinase Inhibitor Regorafenib and Its Active Metabolites, J Pharm Sci, 2017, Sep;106(9):2632-2641 PMID: 28479358

Chemical Information

目录号 A10241
Mechanism of action Inhibitor
分子量 504.5
化学分子式 C16H20N6O.C6H8O7
Solubility DMSO
纯度 >98%
储存方式 at -20°C 2 years
CAS No. 540737-29-9
Synonyms CP690550, tasocitinib citrate, CP-690,550
SMILES code C[C@@H]1CCN(C[C@@H]1N(C)C2=NC=NC3=C2C=CN3)C(=O)CC#N.C(C(=O)O)C(CC(=O)O)(C(=O)O)O
化学名称 3-[(3R,4R)-4-methyl-3-[methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]piperidin-1-yl]-3-oxopropanenitrile citrate salt

生物活性

Description
CP-690550 (Tofacitinib citrate) is an orally available, highly selective inhibitor of the Janus kinase (JAK) family of enzymes.
Targets
Target Value
JAK3IC50: 1nM
JAK2IC50: 20nM
JAK1IC50: 112nM
ROCK2IC50: 3.4μM
LCKIC50: 3.87μM
IRKIC50: >10μM
CDK2IC50: >10μM
CDK5IC50: >10μM
EGFRIC50: >10μM
MAPK2/ERK2IC50: >10μM
JNK1/SAPK1cIC50: >10μM
SAPK2a/p38IC50: >10μM
SAPK2b/p38b2IC50: >10μM
SAPK3/p38gIC50: >10μM
SAPK4/p38dIC50: >10μM
MAPKAPK2IC50: >10μM
MAPKAP-K1bIC50: >10μM
MSK1IC50: >10μM
PRAKIC50: >10μM
PKAIC50: >10μM
PKCαIC50: >10μM
PDK-1IC50: >10μM
PKBαIC50: >10μM
SGKIC50: >10μM
p70S6KIC50: >10μM
GSK-3βIC50: >10μM
AMPKIC50: >10μM
Chk1IC50: >10μM
CK2IC50: >10μM
PHKIC50: >10μM
CSKIC50: >10μM
CDK2/CyclinAIC50: >10μM
PI3KIC50: >10μM

溶解性

Solubility (25°C) * In vitro DMSO 100 mg/mL (198.21 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 0.5% methylcellulose 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 19.82 mL 99.11 mL 198.22mL
0.5 mM 3.96 mL 19.82 mL 39.64 mL
1 mM 1.98 mL 9.91 mL 19.82 mL
5 mM 0.4 mL 1.98 mL 3.96 mL

*The above data is based on the productmolecular weight 504.5 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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