Tofacitinib

Name: Tofacitinib
SKU: A17252

目录号: A17252

JAK3/2/1 inhibitor

Product Citations (1)

Tofacitinib Chemical Structure

CAS NO. 477600-75-2

Tofacitinib is an orally available JAK3/2/1 inhibitor with IC50s of 1, 20, and 112 nM, respectively.

库存：现货

规格	价格	数量
50 mg	￥ 810.00
100 mg	￥ 1,400.00
500 mg	￥ 4,140.00

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生物活性

Tofacitinib is an orally available JAK3/2/1 inhibitor with IC50s of 1, 20, and 112 nM, respectively.

溶解度 *

In vitro (25°C)	DMSO	Warmed: 56 mg/mL (179.27 mM)
	Water	Insoluble
	Ethanol	Insoluble
In vivo	2% DMSO+30% PEG 300+ddH2O	4 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	32.01 mL	160.07 mL	320.13 mL
0.5 mM	6.4 mL	32.01 mL	64.03 mL
1 mM	3.2 mL	16.01 mL	32.01 mL
5 mM	0.64 mL	3.2 mL	6.4 mL

*The above data is based on the productmolecular weight 312.37. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

化学数据

目录号	A17252
作用机制	Inhibitor (抑制剂)
M. Wt	312.37
Formula	C16H20N6O
Purity	>99%
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
CAS No.	477600-75-2
Synonyms	Tasocitinib; CP-690550
SMILES	O=C(CC#N)N1C[C@H](N(C2=C3C(NC=C3)=NC=N2)C)[C@H](C)CC1