CSRM617 hydrochloride is a selective inhibitor of the transcription factor ONECUT2, serving as a critical regulator of androgen receptor activity. This compound exhibits a binding affinity with a Kd of 7.43 µM, directly targeting the OC2-HOX domain. In biological assays, CSRM617 hydrochloride has been shown to induce apoptosis, characterized by the cleavage of Caspase-3 and PARP. Its efficacy and tolerability have been demonstrated in prostate cancer mouse models, making it a valuable tool for research in cancer biology.
CSRM617 hydrochloride is a selective inhibitor of the transcription factor ONECUT2, serving as a critical regulator of androgen receptor activity. This compound exhibits a binding affinity with a Kd of 7.43 µM, directly targeting the OC2-HOX domain. In biological assays, CSRM617 hydrochloride has been shown to induce apoptosis, characterized by the cleavage of Caspase-3 and PARP. Its efficacy and tolerability have been demonstrated in prostate cancer mouse models, making it a valuable tool for research in cancer biology.
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