Cyt387 (Momelotinib)

目录号: A10263

JAK 抑制剂

Cyt387 (Momelotinib) Chemical Structure

CAS NO. 1056634-68-4

Cyt387 (Momelotinib)是Janus激酶JAK1和JAK2的抑制剂,可作为ATP竞争者,IC50值分别为11和18 nM。

库存: 现货

规格 价格 数量
10 mg
¥ 900.00
25 mg
¥ 1,600.00
50 mg
¥ 2,800.00
200 mg
¥ 6,500.00
10mM * 1mL in DMSO
¥ 600.00
Warning 产品仅用于科学研究,不针对患者销售,望谅解.

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Cyt387 (Momelotinib)是Janus激酶JAK1和JAK2的抑制剂,可作为ATP竞争者,IC50值分别为11和18 nM。
靶点信息
JAK1 JAK2 JAK3
11 nM18 nM155 nM
In vitro (25°C) DMSO 83 mg/mL (200.26 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 30% PEG400/0.5% Tween80/5% propylene glycol 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 24.13 mL 120.63 mL 241.25 mL
0.5 mM 4.83 mL 24.13 mL 48.25 mL
1 mM 2.41 mL 12.06 mL 24.13 mL
5 mM 0.48 mL 2.41 mL 4.83 mL

*The above data is based on the productmolecular weight 414.5 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

目录号 A10263
MECHANISM OF ACTION Inhibitor
M. Wt 414.5
Formula C23H22N6O2
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 1056634-68-4
Synonyms CYT 11387, Cyt-387
SMILES C1COCCN1C2=CC=C(C=C2)NC3=NC=CC(=N3)C4=CC=C(C=C4)C(=O)NCC#N

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