EGF816 (Nazartinib)
目录号: A14416
EGFR T790M 抑制剂
EGF816 是一种新型的共价抑制剂,针对突变选择性的 EGFR;能够克服 NSCLC 中 T790M 介导的抗药性。
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重要通知:仅供研究使用。我们不向患者销售。
重要通知:仅供研究使用。我们不向患者销售。
| Discription | EGF816 is a novel covalent inhibitor of mutant-selective EGFR; overcomes T790M-mediated resistance in NSCLC. | |||||
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| Targets |
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| Cell Research |
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| 目录号 | A14416 |
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| 分子式 | C26H31ClN6O2 |
| 分子量 | 495.02 |
| CAS号 | 1508250-71-2 |
| SMILES | CC1=NC=CC(=C1)C(=O)NC2=NC3=C(N2C4CCCCN(C4)C(=O)C=CCN(C)C)C(=CC=C3)Cl |
| 其他名称 | EGF-816, EGF 816, Nazartinib |
| 储存条件 | Store lyophilized at -20ºC, keep desiccated. |
| In vitro | DMSO | 92 mg/mL (185.85 mM) | |
| Water | Insoluble | ||
| Ethanol | 92 mg/mL (185.85 mM) | ||
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* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
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| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 20.2 mL | 101.01 mL | 202.01 mL |
| 0.5 mM | 4.04 mL | 20.2 mL | 40.4 mL |
| 1 mM | 2.02 mL | 10.1 mL | 20.2 mL |
| 5 mM | 0.4 mL | 2.02 mL | 4.04 mL |
Calculate the dilution required to prepare a stock solution. This equation is commonly abbreviated as: C1V1 = C2V2