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Nazartinib mesylate (EGF816 mesylate) is a novel, covalent mutant-selective EGFR inhibitor, with Ki and Kinact of 31 nM and 0.222 min?1 on EGFR(L858R/790M) mutant, respectively.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 16.92 mL | 84.59 mL | 169.17 mL |
| 0.5 mM | 3.38 mL | 16.92 mL | 33.83 mL |
| 1 mM | 1.69 mL | 8.46 mL | 16.92 mL |
| 5 mM | 0.34 mL | 1.69 mL | 3.38 mL |
*The above data is based on the productmolecular weight 591.12. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A21741 |
|---|---|
| 作用机制 | Inhibitor (抑制剂) |
| M. Wt | 591.12 |
| Formula | C27H35ClN6O5S |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 1508250-72-3 |
| Synonyms | EGF816 (mesylate), EGF 816, EGF-816 |
| SMILES | O=C(C1=CC(C)=NC=C1)NC2=NC3=CC=CC(Cl)=C3N2[C@H]4CN(C(/C=C/CN(C)C)=O)CCCC4.CS(=O)(O)=O |
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