EHT 5372 is a potent and selective inhibitor of the DYRK family of kinases, demonstrating IC50 values of 0.22 nM for DYRK1A and 0.28 nM for DYRK1B. It exhibits notable inhibition against other members of the DYRK family and related kinases, making it a valuable tool for investigating the role of DYRKs in cellular signaling pathways. EHT 5372 is primarily utilized in research applications focused on neurodegenerative diseases and cancer, facilitating studies on cell proliferation, differentiation, and apoptosis.
EHT 5372 is a potent and selective inhibitor of the DYRK family of kinases, demonstrating IC50 values of 0.22 nM for DYRK1A and 0.28 nM for DYRK1B. It exhibits notable inhibition against other members of the DYRK family and related kinases, making it a valuable tool for investigating the role of DYRKs in cellular signaling pathways. EHT 5372 is primarily utilized in research applications focused on neurodegenerative diseases and cancer, facilitating studies on cell proliferation, differentiation, and apoptosis.
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