Erlotinib

Name: Erlotinib
SKU: A11416

目录号: A11416

EGFR 抑制剂

Product Citations (5)

Erlotinib Chemical Structure

CAS NO. 183321-74-6

Erlotinib是一种表皮生长因子受体抑制剂（EGFR抑制剂），抑制纯化 EGFR 激酶的 IC50 为2 nM。厄洛替尼以可逆方式与受体的三磷酸腺苷（ATP）结合位点结合。为了传递信号，需要将两个EGFR分子聚在一起形成同型二聚体。然后，这些分子利用ATP分子在酪氨酸残基上彼此进行反磷酸化，从而产生磷酸酪氨酸残基，将磷酸酪氨酸结合蛋白募集到EGFR，从而组装将信号级联转导至细胞核或激活其他细胞生化过程的蛋白复合物。当厄洛替尼与EGFR结合时，就不可能在EGFR中形成磷酸酪氨酸残基，并且不会引发信号级联。

库存：现货

规格	价格	数量
5000 mg	￥ 2,000.00
10000 mg	￥ 3,500.00
20000 mg	￥ 6,000.00

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生物活性

溶解度 *

In vitro (25°C)	DMSO	68 mg/mL (172.83 mM)
	Water	Insoluble
	Ethanol	Warmed: 13 mg/mL
In vivo	5% DMSO+30% PEG 300+5% Tween 80+ddH2O	5 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	25.42 mL	127.08 mL	254.17 mL
0.5 mM	5.08 mL	25.42 mL	50.83 mL
1 mM	2.54 mL	12.71 mL	25.42 mL
5 mM	0.51 mL	2.54 mL	5.08 mL

*The above data is based on the productmolecular weight 393.443. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

化学数据

目录号	A11416
作用机制	Inhibitor (抑制剂)
M. Wt	393.443
Formula	C22H23N3O4?
Purity	>99%
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
CAS No.	183321-74-6
Synonyms	CP-358,774, CP-358774, CP358774, OSI-774, OSI 774, OSI774, Erlotinib free base.
SMILES	COCCOC1=CC2=NC=NC(NC3=CC=CC(C#C)=C3)=C2C=C1OCCOC