GDC-0941 (Pictilisib)

目录号: A10421

PI3K inhibitor

GDC-0941 (Pictilisib) Chemical Structure

CAS NO. 957054-30-7

GDC-0941 is a potent, selective, orally bioavailable inhibitor of class I PI3 kinase (PI3K) , with IC50 values (nM) of 3, 33, 3, 75, 1230 and 580 for p110 α, β, δ and γ isoforms, DNA-PK and mTOR respectively.

库存: 现货

规格 价格 数量
5 mg
¥ 400.00
10 mg
¥ 500.00
50 mg
¥ 750.00
200 mg
¥ 2,100.00
10mM * 1mL in DMSO
¥ 500.00
Warning 产品仅用于科学研究,不针对患者销售,望谅解.

详情

GDC-0941 is a potent, selective, orally bioavailable inhibitor of class I PI3 kinase (PI3K) , with IC50 values (nM) of 3, 33, 3, 75, 1230 and 580 for p110 α, β, δ and γ isoforms, DNA-PK and mTOR respectively.
Targets
Target Value
p110αIC50: 3nM
p110δIC50: 3nM
p110βIC50: 33nM
p110γIC50: 75nM
mTORKiapp0.58μM
C2βIC50: 0.67μM
DNA-PKIC50: 1.23μM
Vps34IC50: >10μM
In vitro (25°C) DMSO 44 mg/mL (85.66 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 1% DMSO/30% polyethylene glycol/1% Tween 80 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 19.47 mL 97.35 mL 194.7 mL
0.5 mM 3.89 mL 19.47 mL 38.94 mL
1 mM 1.95 mL 9.74 mL 19.47 mL
5 mM 0.39 mL 1.95 mL 3.89 mL

*The above data is based on the productmolecular weight 513.6 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

目录号 A10421
MECHANISM OF ACTION Inhibitor
M. Wt 513.6
Formula C23H27N7O3S2
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 957054-30-7
Synonyms GDC0941
SMILES CS(=O)(=O)N1CCN(CC1)CC2=CC3=C(S2)C(=NC(=N3)C4=C5C=NNC5=CC=C4)N6CCOCC6

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