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GDC-0941 (Pictilisib)


PI3K 抑制剂

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产品目录号: A10421


产品名 目录号 价格 数量
GDC-0941 5mg A10421-5
¥ 400.00
GDC-0941 10mg A10421-10
¥ 500.00
GDC-0941 50mg A10421-50
¥ 750.00
GDC-0941 200mg A10421-200
¥ 2,100.00
GDC-0941 10mM * 1mL in DMSO A10421-10mM-D
¥ 500.00



GDC-0941 is a potent, selective, orally bioavailable inhibitor of class I PI3 kinase (PI3K) , with IC50 values (nM) of 3, 33, 3, 75, 1230 and 580 for p110 α, β, δ and γ isoforms, DNA-PK and mTOR respectively.

GDC-0941 (Pictilisib)




顾客使用 Adooq 产品发表的高质量科研文献
Adooq 顾客使用 GDC-0941 (Pictilisib) 发表的文献 (2)
  • Li T, .et al. Bruton's tyrosine kinase potentiates ALK signaling and serves as a potential therapeutic target of neuroblastoma, Oncogene, 2018, Nov;37(47):6180-6194 PMID: 30013190
  • Joo Sang Lee, .et al. Harnessing synthetic lethality to predict the response to cancer treatment, Nat Commun, 2018, 9: 2546 PMID: 29959327

Chemical Information

目录号 A10421
Mechanism of action Inhibitor
分子量 513.6
化学分子式 C23H27N7O3S2
Solubility DMSO
纯度 >98%
储存方式 at -20°C 2 years
CAS No. 957054-30-7
Synonyms GDC0941
化学名称 2-(1H-Indazol-4-yl)-6-[[4-(methylsulfonyl)-1-piperazinyl]methyl]-4-(4-morpholinyl)thieno[3,2-d]pyrimidine


GDC-0941 is a potent, selective, orally bioavailable inhibitor of class I PI3 kinase (PI3K) , with IC50 values (nM) of 3, 33, 3, 75, 1230 and 580 for p110 α, β, δ and γ isoforms, DNA-PK and mTOR respectively.
Target Value
p110αIC50: 3nM
p110δIC50: 3nM
p110βIC50: 33nM
p110γIC50: 75nM
C2βIC50: 0.67μM
DNA-PKIC50: 1.23μM
Vps34IC50: >10μM


Solubility (25°C) * In vitro DMSO 44 mg/mL (85.66 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 1% DMSO/30% polyethylene glycol/1% Tween 80 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.


Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 19.47 mL 97.35 mL 194.7mL
0.5 mM 3.89 mL 19.47 mL 38.94 mL
1 mM 1.95 mL 9.74 mL 19.47 mL
5 mM 0.39 mL 1.95 mL 3.89 mL

*The above data is based on the productmolecular weight 513.6 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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