GDC-0941 (Pictilisib)

目录号: A10421

PI3K 抑制剂

GDC-0941 (Pictilisib)

GDC-0941 (Pictilisib) Chemical Structure

CAS NO. 957054-30-7

GDC-0941 (Pictilisib)是一种强效、选择性、口服生物可利用的I类PI3激酶(PI3K)抑制剂,p110 α、β、δ和γ亚型、DNA-PK和mTOR的IC50值分别为3、33、3、75、1230和580 nM。

库存: 现货

规格 价格 数量
5 mg
¥ 400.00
10 mg
¥ 500.00
50 mg
¥ 750.00
200 mg
¥ 2,100.00
10mM * 1mL in DMSO
¥ 500.00
Warning 产品仅用于科学研究,不针对患者销售,望谅解.

产品详情

GDC-0941 (Pictilisib)是一种强效、选择性、口服生物可利用的I类PI3激酶(PI3K)抑制剂,p110 α、β、δ和γ亚型、DNA-PK和mTOR的IC50值分别为3、33、3、75、1230和580 nM。
Targets
Target Value
p110αIC50: 3nM
p110δIC50: 3nM
p110βIC50: 33nM
p110γIC50: 75nM
mTORKiapp0.58μM
C2βIC50: 0.67μM
DNA-PKIC50: 1.23μM
Vps34IC50: >10μM
In vitro (25°C) DMSO 40 mg/mL (77.87 mM)
Water Insoluble
Ethanol Insoluble
In vivo 2% DMSO+30% PEG 300+5% Tween 80+ddH2O 4 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 19.47 mL 97.35 mL 194.7 mL
0.5 mM 3.89 mL 19.47 mL 38.94 mL
1 mM 1.95 mL 9.74 mL 19.47 mL
5 mM 0.39 mL 1.95 mL 3.89 mL

*The above data is based on the productmolecular weight 513.6 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

目录号 A10421
作用机制 Inhibitor (抑制剂)
M. Wt 513.6
Formula C23H27N7O3S2
Purity >99%
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

CAS No. 957054-30-7
Synonyms GDC0941
SMILES CS(=O)(=O)N1CCN(CC1)CC2=CC3=C(S2)C(=NC(=N3)C4=C5C=NNC5=CC=C4)N6CCOCC6

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