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Pictilisib dimethanesulfonate (GDC-0941 dimethanesulfonate) is a potent inhibitor of PI3Kα/δ with IC50 of 3 nM, with modest selectivity against p110β (11-fold) and p110γ (25-fold).
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 14.17 mL | 70.84 mL | 141.67 mL |
| 0.5 mM | 2.83 mL | 14.17 mL | 28.33 mL |
| 1 mM | 1.42 mL | 7.08 mL | 14.17 mL |
| 5 mM | 0.28 mL | 1.42 mL | 2.83 mL |
*The above data is based on the productmolecular weight 705.85. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A11444 |
|---|---|
| 作用机制 | Inhibitor (抑制剂) |
| M. Wt | 705.85 |
| Formula | C25H35N7O9S4 |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 957054-33-0 |
| Synonyms | GDC-0941 dimethanesulfonate; GDC-0941 2 MeSO3H salt |
| SMILES | O=S(N1CCN(CC1)CC2=CC3=C(S2)C(N4CCOCC4)=NC(C5=CC=CC6=C5C=NN6)=N3)(C)=O.O=S(O)(C)=O.O=S(O)(C)=O |
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