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Gefitinib-based PROTAC 3, conjugating an EGFR binding element to a VHL ligand via a linker, induces EGFR degradation with DC50s of 11.7 nM and 22.3 nM in HCC827(exon 19 del) and H3255 (L858R mutantion) cells, respectively.
| In vitro | DMSO | 92 mg/mL (98.44 mM) | |
| Water | Insoluble | ||
| Ethanol | 92 mg/mL (98.44 mM) | ||
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 10.7 mL | 53.5 mL | 107.01 mL |
| 0.5 mM | 2.14 mL | 10.7 mL | 21.4 mL |
| 1 mM | 1.07 mL | 5.35 mL | 10.7 mL |
| 5 mM | 0.21 mL | 1.07 mL | 2.14 mL |
*The above data is based on the productmolecular weight 934.51. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A19093 |
|---|---|
| M. Wt | 934.51 |
| Formula | C47H57ClFN7O8S |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 2230821-27-7 |
| SMILES | O=C([C@H]1N(C([C@@H](NC(CCOCCOCCCCCOC2=CC3=C(NC4=CC=C(F)C(Cl)=C4)N=CN=C3C=C2OC)=O)C(C)(C)C)=O)C[C@H](O)C1)NCC5=CC=C(C6=C(C)N=CS6)C=C5 |
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