Gefitinib (Iressa)

目录号: A10422

EGFR Inhibitor

Gefitinib (Iressa) Chemical Structure

CAS NO. 184475-35-2

Gefitinib is an EGFR inhibitor, which interrupts signaling through the epidermal growth factor receptor (EGFR) in target cells.

库存: 现货

规格 价格 数量
100 mg
¥ 400.00
250 mg
¥ 500.00
500 mg
¥ 600.00
10mM * 1mL in DMSO
¥ 500.00
Warning 产品仅用于科学研究,不针对患者销售,望谅解.

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Gefitinib is an EGFR inhibitor, which interrupts signaling through the epidermal growth factor receptor (EGFR) in target cells.
靶点信息
Tyr1173 (NR6W cells) Tyr1173 (NR6wtEGFR cells) Tyr992 (NR6wtEGFR cells) Tyr992 (NR6W cells)
26 nM37 nM37 nM57 nM
In vitro (25°C) DMSO 89 mg/mL (199.14 mM)
Water <1 mg/mL (<1 mM)
Ethanol 4 mg/mL (8.95 mM)
In vivo 0.5% methylcellulose/0.2% Tween 80 12 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 22.38 mL 111.88 mL 223.76 mL
0.5 mM 4.48 mL 22.38 mL 44.75 mL
1 mM 2.24 mL 11.19 mL 22.38 mL
5 mM 0.45 mL 2.24 mL 4.48 mL

*The above data is based on the productmolecular weight 446.9 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

目录号 A10422
MECHANISM OF ACTION Inhibitor
M. Wt 446.9
Formula C22H24ClFN4O3
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 184475-35-2
Synonyms ZD-1839
SMILES COC1=C(C=C2C(=C1)N=CN=C2NC3=CC(=C(C=C3)F)Cl)OCCCN4CCOCC4

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