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Gemcitabine HCl (Gemzar)

促销

DNA/RNA Synthesis 抑制剂

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产品目录号: A10423

库存状态:中国现货中国现货

产品名 目录号 价格 数量
Gemcitabine HCl 25mg A10423-25
¥ 300.00
Gemcitabine HCl 50mg A10423-50
¥ 400.00
Gemcitabine HCl 100mg A10423-100
¥ 500.00
Gemcitabine HCl 200mg A10423-200
¥ 600.00

产品仅用于研究,不针对患者销售,望谅解.

产品简介

Gemcitabine (Gemzar) is a newer chemotherapy drug acting by replacing one of the building blocks of nucleic acids during DNA replication in cancer cells, preventing tumor growth.

Gemcitabine HCl (Gemzar)

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顾客使用 Adooq 产品发表的高质量科研文献
Adooq 顾客使用 Gemcitabine HCl (Gemzar) 发表的文献 (1)
  • G. R. Iglesias, .et al. Hyperthermia-Triggered Gemcitabine Release from Polymer-Coated Magnetite Nanoparticles, Polymers, 2018, 10(3), 269

Chemical Information

目录号 A10423
Mechanism of action Inhibitor
分子量 299.7
化学分子式 C9H11F2N3O4.HCI
Solubility DMSO
纯度 >98%
储存方式 at -20°C 2 years
CAS No. 122111-03-9
Synonyms N/A
SMILES code C1=CN(C(=O)N=C1N)[C@H]2C([C@@H]([C@H](O2)CO)O)(F)F.Cl
化学名称 4-Amino-1-[3,3-difluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]-1H-pyrimidin-2-one hydrochloride

生物活性

Description
Gemcitabine (Gemzar) is a newer chemotherapy drug acting by replacing one of the building blocks of nucleic acids during DNA replication in cancer cells, preventing tumor growth.
Targets
DNA synthesis (Capan2 cells) DNA synthesis (BxPC3 cells) DNA synthesis (MIAPaCa2 cells) DNA synthesis (PANC1 cells)
12 nM18 nM40 nM50 nM

溶解性

Solubility (25°C) * In vitro DMSO <1 mg/mL (<1 mM)
Water 19 mg/mL (63.4 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo Saline 20 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 33.37 mL 166.83 mL 333.67mL
0.5 mM 6.67 mL 33.37 mL 66.73 mL
1 mM 3.34 mL 16.68 mL 33.37 mL
5 mM 0.67 mL 3.34 mL 6.67 mL

*The above data is based on the productmolecular weight 299.7. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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