Icotinib
目录号: A13825
EGFR 抑制剂
Icotinib 是一种强效且特异性的 EGFR 抑制剂，其 IC50 为 5 nM，包括 EGFR、EGFR(L858R)、EGFR(L861Q)、EGFR(T790M) 和 EGFR(T790M, L858R)。
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生物活性
| Discription | Icotinib is a potent and specific EGFR inhibitor with IC50 of 5 nM, including the EGFR, EGFR(L858R), EGFR(L861Q), EGFR(T790M) and EGFR(T790M, L858R). | |||||
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| Cell Research |
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产品信息
| 目录号 | A13825 |
|---|---|
| 分子式 | C22H21N3O4 |
| 分子量 | 391.42 |
| CAS号 | 610798-31-7 |
| SMILES | C#CC1=CC(=CC=C1)NC2=NC=NC3=CC4=C(C=C32)OCCOCCOCCO4 |
| 其他名称 | BPI-2009H |
| 储存条件 | Store lyophilized at -20ºC, keep desiccated. |
溶解性数据
| In vitro (25°C) | DMSO | 66 mg/mL (168.61 mM) | |
| Water | Insoluble | ||
| Ethanol | 6 mg/mL (15.33 mM) | ||
| In vivo | 0.5% CMC | 28 mg/mL | |
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* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
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Preparing Stock Solutions
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 25.55 mL | 127.74 mL | 255.48 mL |
| 0.5 mM | 5.11 mL | 25.55 mL | 51.1 mL |
| 1 mM | 2.55 mL | 12.77 mL | 25.55 mL |
| 5 mM | 0.51 mL | 2.55 mL | 5.11 mL |
Useful Calculator
Calculate the dilution required to prepare a stock solution. This equation is commonly abbreviated as: C1V1 = C2V2
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