JNJ-63576253 is a potent and orally active antagonist of the androgen receptor (AR), exhibiting IC50 values of 37 nM for the F877L mutant AR and 54 nM for wild-type AR in LNCaP cells. This compound serves as a valuable tool for investigating androgen receptor signaling pathways and is particularly relevant for research on castration-resistant prostate cancer (CRPC). Its efficacy in blocking AR activity makes it a significant candidate for therapeutic studies targeting advanced prostate carcinoma.
JNJ-63576253 is a potent and orally active antagonist of the androgen receptor (AR), exhibiting IC50 values of 37 nM for the F877L mutant AR and 54 nM for wild-type AR in LNCaP cells. This compound serves as a valuable tool for investigating androgen receptor signaling pathways and is particularly relevant for research on castration-resistant prostate cancer (CRPC). Its efficacy in blocking AR activity makes it a significant candidate for therapeutic studies targeting advanced prostate carcinoma.
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