LDN193189

Name: LDN193189
SKU: A11205
Price: 245 CNY
Rating: 5 (4 reviews)

目录号: A11205

ALK 抑制剂

4 篇发表文献

LDN193189 是一种高效的小分子 BMP 抑制剂，能够抑制 BMP 类型 I 受体 ALK2（IC50：5 nM）、ALK3（IC50：30 nM）和 ALK6（TGFβ1/BMP 信号传导）以及随后的 SMAD 磷酸化。

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Grouped product items
规格	价格	库存
2mg	¥245.00	现货
5mg	¥420.00	现货
10mg	¥560.00	现货
25mg	¥945.00	现货
50mg	¥1,610.00	现货
100mg	¥2,415.00	现货
200mg	¥3,605.00	现货
1g	¥9,765.00	现货
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重要通知：仅供研究使用。我们不向患者销售。

Data Sheet

SDS

Other Forms of LDN193189

顾客使用 Adooq 产品发表的高质量科研文献

Adooq用户使用LDN193189发表的4篇文献

Lei Wang, .et al. , Theriogenology, 2023, Feb;197:167-176 PMID: 36525856

Trang Thi Huyen Dang, .et al. , Mol Cell Biochem, 2021, May;476(5):2085-2097 PMID: 33517521

Shizu Aikawa, .et al. , EMBO J, 2017, Jul 14; 36(14): 2146-2160 PMID: 28588064

HIROTAKA SOMEYA, .et al. , Int J Mol Med, 2015, May; 35(5): 1169-1178 PMID: 25739055

生物活性

Discription

LDN193189 is a highly potent small molecule BMP inhibitor that inhibits BMP type I receptors ALK2 (IC50: 5 nM), ALK3 (IC50: 30 nM) and ALK6 (TGFβ1/BMP signaling) and subsequent SMAD phosphorylation.

Targets

Target	Value

产品信息

目录号	A11205
分子式	C25H22N6
分子量	406.48
CAS号	1062368-24-4
SMILES	C1CN(CCN1)C2=CC=C(C=C2)C3=CN4C(=C(C=N4)C5=CC=NC6=CC=CC=C56)N=C3
其他名称	LDN-193189
储存条件	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

溶解性数据

In vitro	DMSO	9.8 mg/mL (Ultrasonicate the solution, warm up to 80°C in HCl solution)
	Water	Insoluble
	Ethanol	Insoluble
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	24.6 mL	123.01 mL	246.01 mL
0.5 mM	4.92 mL	24.6 mL	49.2 mL
1 mM	2.46 mL	12.3 mL	24.6 mL
5 mM	0.49 mL	2.46 mL	4.92 mL

Useful Calculator

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* Please check COA/MSDS for correct molecular weight.

Calculate the dilution required to prepare a stock solution.
This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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