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N-Desethyl Sunitinib

VEGFR/PDGFR??/KIT 抑制剂

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产品目录号: A15182

库存状态:中国现货中国现货

产品名 目录号 价格 数量
N-Desethyl Sunitinib 5mg A15182-5
¥ 2,250.00
N-Desethyl Sunitinib 10mg A15182-10
¥ 3,150.00
N-Desethyl Sunitinib 50mg A15182-50
¥ 7,850.00

产品仅用于研究,不针对患者销售,望谅解.

产品简介

N-desethyl sunitinib is a major and pharmacologically active metabolite of sunitinib, which is potent, ATP-competitive VEGFR, PDGFRβ and KIT inhibitor (Ki values are 2, 9, 17, 8 and 4 nM for VEGFR -1, -2, -3, PDGFRβ and KIT respectively).

N-Desethyl Sunitinib

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Chemical Information

目录号 A15182
Mechanism of action Inhibitor
分子量 370.42
化学分子式 C20H23FN4O2
Solubility DMSO
纯度 >98%
储存方式 at -20°C 2 years
CAS No. 356068-97-8
Synonyms SU11662, SU 11662, SU-11662
SMILES code CCNCCNC(=O)C1=C(NC(=C1C)C=C2C3=C(C=CC(=C3)F)NC2=O)C
化学名称 N-[2-(ethylamino)ethyl]-5-[(Z)-(5-fluoro-2-oxo-1H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide

生物活性

Description
N-desethyl sunitinib is a major and pharmacologically active metabolite of sunitinib, which is potent, ATP-competitive VEGFR, PDGFRβ and KIT inhibitor (Ki values are 2, 9, 17, 8 and 4 nM for VEGFR -1, -2, -3, PDGFRβ and KIT respectively).

制备储备液

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 27 mL 134.98 mL 269.96mL
0.5 mM 5.4 mL 27 mL 53.99 mL
1 mM 2.7 mL 13.5 mL 27 mL
5 mM 0.54 mL 2.7 mL 5.4 mL

*The above data is based on the productmolecular weight 370.42. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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