Sunitinib Malate

目录号: A10880

RTK inhibitor

Sunitinib Malate

Sunitinib Malate Chemical Structure

CAS NO. 341031-54-7

Sunitinib Malate是一种多靶点RTK抑制剂,作用于VEGFR2 (Flk-1)和 PDGFRβ,也会抑制c-Kit的活性。用于治疗肾细胞癌(RCC)和伊马替尼耐药的胃肠道间质瘤(GIST)。

库存: 现货

规格 价格 数量
50 mg
¥ 280.00
100 mg
¥ 385.00
200 mg
¥ 595.00
500 mg
¥ 735.00
10mM * 1mL in DMSO
¥ 350.00
Warning 产品仅用于科学研究,不针对患者销售,望谅解.

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Sunitinib Malate是一种多靶点RTK抑制剂,作用于VEGFR2 (Flk-1)和 PDGFRβ,也会抑制c-Kit的活性。用于治疗肾细胞癌(RCC)和伊马替尼耐药的胃肠道间质瘤(GIST)。
Targets
Target Value
Kit
FLT3
PDGFRβIC50: 2nM
VEGFR2IC50: 80nM
FGFR1IC50: 2.9μM
EGFRIC50: >20μM
In vitro (25°C) DMSO 13 mg/mL (24.41 mM)
Water Insoluble
Ethanol Insoluble
In vivo 4% DMSO+30% PEG 300+ddH2O 1 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 18.78 mL 93.88 mL 187.76 mL
0.5 mM 3.76 mL 18.78 mL 37.55 mL
1 mM 1.88 mL 9.39 mL 18.78 mL
5 mM 0.38 mL 1.88 mL 3.76 mL

*The above data is based on the productmolecular weight 532.6 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

目录号 A10880
作用机制 Inhibitor (抑制剂)
M. Wt 532.6
Formula C22H27FN4O2.C4H6O5
Purity >99%
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

CAS No. 341031-54-7
Synonyms SU-11248
SMILES CCN(CC)CCNC(=O)C1=C(NC(=C1C)/C=C\2/C3=C(C=CC(=C3)F)NC2=O)C.C([C@@H](C(=O)O)O)C(=O)O

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