Sunitinib Malate

目录号: A10880

Sunitinib Malate Chemical Structure

CAS NO. 341031-54-7

Sunitinib is an oral, small-molecule, multi-targeted receptor tyrosine kinase (RTK) inhibitor for the treatment of renal cell carcinoma (RCC) and imatinib-resistant gastrointestinal stromal tumor (GIST).

库存: 现货

规格 价格 数量
50 mg
¥ 400.00
100 mg
¥ 550.00
200 mg
¥ 850.00
500 mg
¥ 1,050.00
10mM * 1mL in DMSO
¥ 500.00
Warning 产品仅用于科学研究,不针对患者销售,望谅解.

详情

Sunitinib is an oral, small-molecule, multi-targeted receptor tyrosine kinase (RTK) inhibitor for the treatment of renal cell carcinoma (RCC) and imatinib-resistant gastrointestinal stromal tumor (GIST).
Targets
Target Value
Kit
FLT3
PDGFRβIC50: 2nM
VEGFR2IC50: 80nM
FGFR1IC50: 2.9μM
EGFRIC50: >20μM
In vitro (25°C) DMSO 15 mg/mL (28.16 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 0.5% CMC, pH3.5 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 18.78 mL 93.88 mL 187.76 mL
0.5 mM 3.76 mL 18.78 mL 37.55 mL
1 mM 1.88 mL 9.39 mL 18.78 mL
5 mM 0.38 mL 1.88 mL 3.76 mL

*The above data is based on the productmolecular weight 532.6 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

目录号 A10880
MECHANISM OF ACTION
M. Wt 532.6
Formula C22H27FN4O2.C4H6O5
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 341031-54-7
Synonyms SU-11248
SMILES CCN(CC)CCNC(=O)C1=C(NC(=C1C)/C=C\2/C3=C(C=CC(=C3)F)NC2=O)C.C([C@@H](C(=O)O)O)C(=O)O

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