R406 (Tamatinib)
目录号: A10770
Syk 抑制剂
R406 是一种口服可用的脾酪氨酸激酶抑制剂,其 IC50 为 41 nM。
| Discription | R406 is an orally available spleen tyrosine kinase inhibitor with an IC50 of 41 nM. | |||||
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| Cell Research |
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| 目录号 | A10770 |
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| 分子式 | C22H23FN6O5 |
| 分子量 | 470.5 |
| CAS号 | 841290-80-0 |
| SMILES | CC1(C(=O)NC2=C(O1)C=CC(=N2)NC3=NC(=NC=C3F)NC4=CC(=C(C(=C4)OC)OC)OC)C |
| 其他名称 | R-406 |
| 储存条件 | Store lyophilized at -20ºC, keep desiccated. |
| In vitro (25°C) | DMSO | 18 mg/mL (38.25 mM) | |
| Water | Insoluble | ||
| Ethanol | Insoluble | ||
| In vivo | 1% DMSO+30% polyethylene glycol+1% Tween 80 | 28 mg/mL | |
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* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
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| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 21.25 mL | 106.27 mL | 212.54 mL |
| 0.5 mM | 4.25 mL | 21.25 mL | 42.51 mL |
| 1 mM | 2.13 mL | 10.63 mL | 21.25 mL |
| 5 mM | 0.43 mL | 2.13 mL | 4.25 mL |
Calculate the dilution required to prepare a stock solution. This equation is commonly abbreviated as: C1V1 = C2V2