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R406 besylate

促销

Syk 抑制剂

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产品目录号: A10769

库存状态:中国现货中国现货

产品名 目录号 价格 数量
R406 2mg A10769-2
¥ 500.00
R406 5mg A10769-5
¥ 1,000.00
R406 10mg A10769-10
¥ 1,500.00
R406 50mg A10769-50
¥ 5,000.00
R406 10mM * 1mL in DMSO A10769-10mM-D
¥ 3,730.00

产品仅用于研究,不针对患者销售,望谅解.

产品简介

R406 is an orally available spleen tyrosine kinase inhibitor with an IC50 of 41 nM.

R406 besylate

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Chemical Information

目录号 A10769
Mechanism of action Inhibitor
分子量 628.6
化学分子式 C22H23FN6O5.C6H6O3S
Solubility DMSO
纯度 >98%
储存方式 at -20°C 2 years
CAS No. 841290-81-1
Synonyms R-406
SMILES code CC1(C(=O)NC2=C(O1)C=CC(=N2)NC3=NC(=NC=C3F)NC4=CC(=C(C(=C4)OC)OC)OC)C.C1=CC=C(C=C1)S(=O)(=O)O
化学名称 N4-(2,2-dimethyl-3-oxo-4H-pyrid[1,4]oxazin-6-yl)-5-fluoro-N2-(3,4,5-trimethoxyphenyl)-2,4-pyrimidinediamine,monobenzenesulfonate

生物活性

Description
R406 is an orally available spleen tyrosine kinase inhibitor with an IC50 of 41 nM.
Targets
Flt3 (Cell-free assay) Syk (Cell-free assay)
N/A41 nM

溶解性

Solubility (25°C) * In vitro DMSO 126 mg/mL (200.43 mM)
Water <1 mg/mL (<1 mM)
Ethanol 8 mg/mL (12.72 mM)
In vivo 30% PEG400/0.5% Tween80/5% propylene glycol 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 15.91 mL 79.54 mL 159.08mL
0.5 mM 3.18 mL 15.91 mL 31.82 mL
1 mM 1.59 mL 7.95 mL 15.91 mL
5 mM 0.32 mL 1.59 mL 3.18 mL

*The above data is based on the productmolecular weight 628.6. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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