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R788 (Fostamatinib)


Syk 抑制剂

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产品目录号: A11926


产品名 目录号 价格 数量
R788 2mg A11926-2
¥ 600.00
R788 5mg A11926-5
¥ 1,000.00
R788 10mg A11926-10
¥ 1,800.00
R788 25mg A11926-25
¥ 4,000.00
R788 (Fostamatinib) 10mM * 1mL in DMSO A11926-10mM-D
¥ 2,330.00



R788 (Fostamatinib) is an important spleen tyrosine kinase (Syk) inhibitor, showing efficacy against kinase-mediated IgG Fc gamma receptor signaling.

R788 (Fostamatinib)




顾客使用 Adooq 产品发表的高质量科研文献
Adooq 顾客使用 R788 (Fostamatinib) 发表的文献 (4)
  • Mahon OR, .et al. Orthopaedic implant materials drive M1 macrophage polarization in a spleen tyrosine kinase- and mitogen-activated protein kinase-dependent manner, Acta Biomater, 2018, Jan;65:426-435 PMID: 29104084
  • Emma M. Corr, .et al. Osteoarthritis-associated basic calcium phosphate crystals activate membrane proximal kinases in human innate immune cells, Arthritis Res Ther, 2017, 19: 23 PMID: 28173838
  • Cunningham CC, .et al. Intra-articular basic calcium phosphate and monosodium urate crystals inhibit anti-osteoclastogenic cytokine signalling, Osteoarthritis Cartilage, 2016, Dec;24(12):2141-2152 PMID: 27426968
  • Corr EM, .et al. Cholesterol crystals activate Syk and PI3 kinase in human macrophages and dendritic cells, Atherosclerosis, 2016, Aug;251:197-205 PMID: 27356299

Chemical Information

目录号 A11926
Mechanism of action Inhibitor
分子量 580.5
化学分子式 C23H26FN6O9P
Solubility DMSO
纯度 >98%
储存方式 at -20°C 2 years
CAS No. 901119-35-5
Synonyms R-788
SMILES code CC1(C(=O)N(C2=C(O1)C=CC(=N2)NC3=NC(=NC=C3F)NC4=CC(=C(C(=C4)OC)OC)OC)COP(=O)(O)O)C
化学名称 (6-((5-fluoro-2-((3,4,5-trimethoxyphenyl)amino)pyrimidin-4-yl)amino)-2,2-dimethyl-3-oxo-2H-pyrido[3,2-b][1,4]oxazin-4(3H)-yl)methyl dihydrogen phosphate


R788 (Fostamatinib) is an important spleen tyrosine kinase (Syk) inhibitor, showing efficacy against kinase-mediated IgG Fc gamma receptor signaling.
Syk Adenosine A3 receptor Adenosine transporter Monoamine transporter
41 nM81 nM1.84 μM2.74 μM


Solubility (25°C) * In vitro DMSO 116 mg/mL (199.84 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 30% PEG400/0.5% Tween80/5% propylene glycol 20 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.


Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 17.23 mL 86.13 mL 172.27mL
0.5 mM 3.45 mL 17.23 mL 34.45 mL
1 mM 1.72 mL 8.61 mL 17.23 mL
5 mM 0.34 mL 1.72 mL 3.45 mL

*The above data is based on the productmolecular weight 580.5 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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