R935788 (Fostamatinib disodium, R788)

目录号: A10771

Syk Inhibitor

R935788 (Fostamatinib disodium, R788) Chemical Structure

CAS NO. 1025687-58-4

R935788 (Fostamatinib disodium) is a potent orally available inhibitor of Syk that inhibits tumor growth in the Eμ- TCL1 transgenic mouse model of CLL by blocking antigen-dependent B-cell receptor signaling.

库存: 现货

规格 价格 数量
5 mg
¥ 900.00
10 mg
¥ 1,300.00
50 mg
¥ 4,000.00
100 mg
¥ 6,380.00
Warning 产品仅用于科学研究,不针对患者销售,望谅解.

产品详情

R935788 (Fostamatinib disodium) is a potent orally available inhibitor of Syk that inhibits tumor growth in the Eμ- TCL1 transgenic mouse model of CLL by blocking antigen-dependent B-cell receptor signaling.
靶点信息
Syk (Cell-free assay)
41 nM
In vitro (25°C) DMSO 0.4 mg/mL (<1 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 0.5% CMC/0.25% Tween 80,pH6.5 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 16.02 mL 80.08 mL 160.15 mL
0.5 mM 3.2 mL 16.02 mL 32.03 mL
1 mM 1.6 mL 8.01 mL 16.02 mL
5 mM 0.32 mL 1.6 mL 3.2 mL

*The above data is based on the productmolecular weight 624.4 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

目录号 A10771
MECHANISM OF ACTION Inhibitor
M. Wt 624.4
Formula C23H24FN6O9P.2Na
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 1025687-58-4
Synonyms R-935788, Fostamatinib disodium, R788
SMILES CC1(C(=O)N(C2=C(O1)C=CC(=N2)NC3=NC(=NC=C3F)NC4=CC(=C(C(=C4)OC)OC)OC)COP(=O)([O-])[O-])C.[Na+].[Na+]

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