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R935788 (Fostamatinib disodium, R788)

Syk 抑制剂

158 Customer Reviews
产品目录号: A10771

库存状态:中国现货中国现货

产品名 目录号 价格 数量
R935788 5mg A10771-5
¥ 900.00
R935788 10mg A10771-10
¥ 1,500.00
R935788 50mg A10771-50
¥ 4,300.00
R935788 100mg A10771-100
¥ 7,500.00

产品仅用于研究,不针对患者销售,望谅解.

产品简介

R935788 (Fostamatinib disodium) is a potent orally available inhibitor of Syk that inhibits tumor growth in the Eμ- TCL1 transgenic mouse model of CLL by blocking antigen-dependent B-cell receptor signaling.

R935788 (Fostamatinib disodium, R788)

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Chemical Information

目录号 A10771
Mechanism of action Inhibitor
分子量 624.4
化学分子式 C23H24FN6O9P.2Na
Solubility DMSO
纯度 >98%
储存方式 at -20°C 2 years
CAS No. 1025687-58-4
Synonyms R-935788, Fostamatinib disodium, R788
SMILES code CC1(C(=O)N(C2=C(O1)C=CC(=N2)NC3=NC(=NC=C3F)NC4=CC(=C(C(=C4)OC)OC)OC)COP(=O)([O-])[O-])C.[Na+].[Na+]
化学名称 (6-((5-Fluoro-2-((3,4,5-trimethoxyphenyl)amino)pyrimidin-4-yl)amino)-2,2-dimethyl-3-oxo-2H-pyrido[3,2-b][1,4]oxazin-4(3H)-yl)methyl dihydrogen phosphate, disodium

生物活性

Description
R935788 (Fostamatinib disodium) is a potent orally available inhibitor of Syk that inhibits tumor growth in the Eμ- TCL1 transgenic mouse model of CLL by blocking antigen-dependent B-cell receptor signaling.
Targets
Syk (Cell-free assay)
41 nM

溶解性

Solubility (25°C) * In vitro DMSO 0.4 mg/mL (<1 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 0.5% CMC/0.25% Tween 80,pH6.5 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 16.02 mL 80.08 mL 160.15mL
0.5 mM 3.2 mL 16.02 mL 32.03 mL
1 mM 1.6 mL 8.01 mL 16.02 mL
5 mM 0.32 mL 1.6 mL 3.2 mL

*The above data is based on the productmolecular weight 624.4 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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