Regorafenib (BAY 73-4506)

目录号: A10250

VEGFR inhibitor

Regorafenib (BAY 73-4506) Chemical Structure

CAS NO. 755037-03-7

Regorafenib(BAY 73-4506)是一种多激酶抑制剂,IC50为17、40和69 nM c-KIT,VEGFR2,B-Raf。 Regorafenib(BAY 73-4506)是一种针对肿瘤及其脉管系统的口服生物利用型多激酶抑制剂。

库存: 现货

规格 价格 数量
25 mg
¥ 500.00
100 mg
¥ 1,300.00
10mM * 1mL in DMSO
¥ 690.00
Warning 产品仅用于科学研究,不针对患者销售,望谅解.

详情

Regorafenib(BAY 73-4506)是一种多激酶抑制剂,IC50为17、40和69 nM c-KIT,VEGFR2,B-Raf。 Regorafenib(BAY 73-4506)是一种针对肿瘤及其脉管系统的口服生物利用型多激酶抑制剂。
Targets
Target Value
RETIC50: 1.5nM
Raf-1IC50: 2.5nM
VEGFR2IC50: 4.2nM
KitIC50: 7nM
VEGFR1IC50: 13nM
B-Raf(V600E)IC50: 19nM
PDGFRβIC50: 22nM
B-RafIC50: 28nM
VEGFR3IC50: 46nM
FGFR1IC50: 202nM
Tie-2IC50: 311nM
In vitro (25°C) DMSO 97 mg/mL (200.9 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 30% PEG400/0.5% Tween80/5% propylene glycol 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 20.71 mL 103.56 mL 207.13 mL
0.5 mM 4.14 mL 20.71 mL 41.43 mL
1 mM 2.07 mL 10.36 mL 20.71 mL
5 mM 0.41 mL 2.07 mL 4.14 mL

*The above data is based on the productmolecular weight 482.8. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

目录号 A10250
MECHANISM OF ACTION Inhibitor
M. Wt 482.8
Formula C21H15ClF4N4O3
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 755037-03-7
Synonyms N/A
SMILES CNC(=O)C1=NC=CC(=C1)OC2=CC(=C(C=C2)NC(=O)NC3=CC(=C(C=C3)Cl)C(F)(F)F)F

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