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Regorafenib monohydrate

Tyrosine kinase 抑制剂

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产品目录号: A15218

库存状态:中国现货中国现货

产品名 目录号 价格 数量
Regorafenib monohydrate 50mg A15218-50
¥ 900.00
Regorafenib monohydrate 100mg A15218-100
¥ 1,200.00
Regorafenib monohydrate 200mg A15218-200
¥ 1,900.00

产品仅用于研究,不针对患者销售,望谅解.

产品简介

Regorafenib is a multi-target inhibitor for VEGFR1, VEGFR2, VEGFR3, PDGFRβ, Kit, RET and Raf-1 with IC50 of 13 nM/4.2 nM/46 nM, 22 nM, 7 nM, 1.5 nM and 2.5 nM, respectively.

Regorafenib monohydrate

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Chemical Information

目录号 A15218
Mechanism of action Inhibitor
分子量 500.83
化学分子式 C21H17ClF4N4O4
Solubility DMSO
纯度 >98%
储存方式 at -20°C 2 years
CAS No. 1019206-88-2
Synonyms BAY 73-4506 monohydrate
SMILES code CNC(=O)C1=NC=CC(=C1)OC2=CC(=C(C=C2)NC(=O)NC3=CC(=C(C=C3)Cl)C(F)(F)F)F.O
化学名称 4-[4-[[4-chloro-3-(trifluoromethyl)phenyl]carbamoylamino]-3-fluorophenoxy]-N-methylpyridine-2-carboxamide;hydrate

生物活性

Description
Regorafenib is a multi-target inhibitor for VEGFR1, VEGFR2, VEGFR3, PDGFRβ, Kit, RET and Raf-1 with IC50 of 13 nM/4.2 nM/46 nM, 22 nM, 7 nM, 1.5 nM and 2.5 nM, respectively.

制备储备液

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 19.97 mL 99.83 mL 199.67mL
0.5 mM 3.99 mL 19.97 mL 39.93 mL
1 mM 2 mL 9.98 mL 19.97 mL
5 mM 0.4 mL 2 mL 3.99 mL

*The above data is based on the productmolecular weight 500.83. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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