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Regorafenib monohydrate

Tyrosine kinase 抑制剂

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产品目录号: A15218


产品名 目录号 价格 数量
Regorafenib monohydrate 50mg A15218-50
¥ 900.00
Regorafenib monohydrate 100mg A15218-100
¥ 1,200.00
Regorafenib monohydrate 200mg A15218-200
¥ 1,900.00



Regorafenib is a multi-target inhibitor for VEGFR1, VEGFR2, VEGFR3, PDGFRβ, Kit, RET and Raf-1 with IC50 of 13 nM/4.2 nM/46 nM, 22 nM, 7 nM, 1.5 nM and 2.5 nM, respectively.

Regorafenib monohydrate




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Chemical Information

目录号 A15218
Mechanism of action Inhibitor
分子量 500.83
化学分子式 C21H17ClF4N4O4
Solubility DMSO
纯度 >98%
储存方式 at -20°C 2 years
CAS No. 1019206-88-2
Synonyms BAY 73-4506 monohydrate
SMILES code CNC(=O)C1=NC=CC(=C1)OC2=CC(=C(C=C2)NC(=O)NC3=CC(=C(C=C3)Cl)C(F)(F)F)F.O
化学名称 4-[4-[[4-chloro-3-(trifluoromethyl)phenyl]carbamoylamino]-3-fluorophenoxy]-N-methylpyridine-2-carboxamide;hydrate


Regorafenib is a multi-target inhibitor for VEGFR1, VEGFR2, VEGFR3, PDGFRβ, Kit, RET and Raf-1 with IC50 of 13 nM/4.2 nM/46 nM, 22 nM, 7 nM, 1.5 nM and 2.5 nM, respectively.


Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 19.97 mL 99.83 mL 199.67mL
0.5 mM 3.99 mL 19.97 mL 39.93 mL
1 mM 2 mL 9.98 mL 19.97 mL
5 mM 0.4 mL 2 mL 3.99 mL

*The above data is based on the productmolecular weight 500.83. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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