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Sivelestat sodium salt

Neutrophil elastase 抑制剂

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产品目录号: A14073

库存状态:中国现货中国现货

产品名 目录号 价格 数量
Sivelestat sodium salt 10mg A14073-10
¥ 700.00
Sivelestat sodium salt 25mg A14073-25
¥ 1,400.00
Sivelestat sodium salt 50mg A14073-50
¥ 2,400.00

产品仅用于研究,不针对患者销售,望谅解.

产品简介

Sivelestat sodium salt is a selective leukocyte elastase inhibitor (IC50 = 44 nM) that displays no activity at a range of other proteases. It inhibits NF-kB activation and LTB4-induced neutrophil transmigration in vitro.

Sivelestat sodium salt

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Chemical Information

目录号 A14073
Mechanism of action Inhibitor
分子量 456.44
化学分子式 C20H21N2NaO7S
Solubility DMSO
纯度 >98%
储存方式 at -20°C 2 years
CAS No. 150374-95-1
Synonyms ONO-5046
SMILES code CC(C)(C)C(=O)OC1=CC=C(C=C1)S(=O)(=O)NC2=CC=CC=C2C(=O)NCC(=O)[O-].[Na+]
化学名称 N-{2-[({4-[(2,2-Dimethylpropanoyl)oxy]phenyl}sulfonyl)amino]benzoyl}glycine sodium salt

生物活性

Description
Sivelestat sodium salt is a selective leukocyte elastase inhibitor (IC50 = 44 nM) that displays no activity at a range of other proteases. It inhibits NF-kB activation and LTB4-induced neutrophil transmigration in vitro.

制备储备液

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 21.91 mL 109.54 mL 219.09mL
0.5 mM 4.38 mL 21.91 mL 43.82 mL
1 mM 2.19 mL 10.95 mL 21.91 mL
5 mM 0.44 mL 2.19 mL 4.38 mL

*The above data is based on the productmolecular weight 456.44. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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