WIZ Degrader 1 is a selective degrader targeting widely interspaced zinc finger motifs (WIZ) with an AC50 of 2 nM. This compound induces the expression of fetal hemoglobin (HbF) with an EC50 of 6 mM, providing a valuable tool for research into inherited blood disorders. Its capability to modulate HbF levels highlights its potential applications in therapeutic strategies for conditions such as sickle cell disease and beta-thalassemia.
WIZ Degrader 1 is a selective degrader targeting widely interspaced zinc finger motifs (WIZ) with an AC50 of 2 nM. This compound induces the expression of fetal hemoglobin (HbF) with an EC50 of 6 mM, providing a valuable tool for research into inherited blood disorders. Its capability to modulate HbF levels highlights its potential applications in therapeutic strategies for conditions such as sickle cell disease and beta-thalassemia.
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