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YM155 (Sepantronium Bromide)


Survivin 抑制剂

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产品目录号: A11002


产品名 目录号 价格 数量
YM155 5mg A11002-5
¥ 400.00
YM155 10mg A11002-10
¥ 700.00
YM155 25mg A11002-25
¥ 1,500.00
YM155 100mg A11002-100
¥ 4,000.00
YM155 10mM * 1mL in DMSO A11002-10mM-D
¥ 500.00



YM155 is a novel small molecule survivin suppressant with an IC50 of 0.54 nM for the inhibition of survivin promoter activity.

YM155 (Sepantronium Bromide)




顾客使用 Adooq 产品发表的高质量科研文献
Adooq 顾客使用 YM155 (Sepantronium Bromide) 发表的文献 (5)
  • Yamamoto M, .et al. AS602801 Sensitizes Ovarian Cancer Stem Cells to Paclitaxel by Down-regulating MDR1, Anticancer Res, 2019, Feb;39(2):609-617 PMID: 30711936
  • V芍zquez-Mellado MJ, .et al. Erythropoietin promotes expression of survivin via STAT3 activation and reduces sensitivity to cisplatin in cervical cancer cells, Oncol Rep, 2018, Nov 27 PMID: 30483799
  • MASAHIRO YAMAMOTO, .et al. AS602801, an Anticancer Stem Cell Candidate Drug, Reduces Survivin Expression and Sensitizes A2780 Ovarian Cancer Stem Cells to Carboplatin and Paclitaxel, Anticancer Res, 2018, Dec 38 (12) 6699-6706 PMID: 30504379
  • Ahn MR, .et al. Both triazolyl ester of ketorolac (15K) and YM155 inhibit the embryonic angiogenesis in ovo (fertilized eggs) via their common PAK1-survivin/VEGF signaling pathway, Drug Discov Ther, 2017, 11(6):300-306 PMID: 29332887
  • MASAYA MINODA, .et al. Antitumor effect of YM155, a novel small-molecule survivin suppressant, via mitochondrial apoptosis in human MFH/UPS, Int J Oncol., 2015, Sep; 47(3): 891每899 PMID: 26166250

Chemical Information

目录号 A11002
Mechanism of action Inhibitor
分子量 443.3
化学分子式 C20H19BrN4O3
Solubility DMSO>89mg/mL Water>89mg/mL Ethanol>24mg/mL
纯度 >98%
储存方式 at -20°C 2 years
CAS No. 781661-94-7
Synonyms N/A
SMILES code CC1=[N+](C2=C(N1CCOC)C(=O)C3=CC=CC=C3C2=O)CC4=NC=CN=C4.[Br-]
化学名称 4,9-Dihydro-1-(2-methoxyethyl)-2-methyl-4,9-dioxo-3-(2-pyrazinylmethyl)-1H-naphth[2,3-d]imidazolium bromide


YM155 is a novel small molecule survivin suppressant with an IC50 of 0.54 nM for the inhibition of survivin promoter activity.
Survivin (HeLa-SURP-luc, CHO-SV40-luc cells)
0.54 nM


Solubility (25°C) * In vitro DMSO 55 mg/mL (124.07 mM)
Water 89 mg/mL (200.77 mM)
Ethanol 6 mg/mL (13.53 mM)
In vivo Saline 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.


Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 22.56 mL 112.79 mL 225.58mL
0.5 mM 4.51 mL 22.56 mL 45.12 mL
1 mM 2.26 mL 11.28 mL 22.56 mL
5 mM 0.45 mL 2.26 mL 4.51 mL

*The above data is based on the productmolecular weight 443.3. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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