Trusted by 10,000+ Scientists since 2006
微信关注
申请试用装

Z-VAD-FMK

促销

Pan Caspase 抑制剂

0 Customer Reviews
产品目录号: A12373

库存状态:中国现货中国现货

产品名 目录号 价格 数量
Z-VAD-FMK 1mg A12373-1
¥ 400.00
Z-VAD-FMK 5mg A12373-5
¥ 1,200.00
Z-VAD-FMK 10mg A12373-10
¥ 2,000.00
Z-VAD-FMK 25mg A12373-25
¥ 3,500.00
Z-VAD-FMK 10mM * 1mL in DMSO A12373-10mM-D
¥ 2,460.00

产品仅用于研究,不针对患者销售,望谅解.

产品简介

Z-VAD-FMK is a cell-permeable, irreversible pan-caspase inhibitor. Inhibits caspase processing and apoptosis induction in tumor cells in vitro (IC50 = 0.0015 - 5.8 mM). Active in vivo.

Z-VAD-FMK

双击上述图片即可查看完整大小

缩小
放大

更多视图

顾客使用 Adooq 产品发表的高质量科研文献
Adooq 顾客使用 Z-VAD-FMK 发表的文献 (13)
  • Fujiki K, .et al. Blockade of ALK4/5 signaling suppresses cadmium- and erastin-induced cell death in renal proximal tubular epithelial cells via distinct signaling mechanisms, Cell Death Differ, 2019, Feb 25 PMID: 30804470
  • T Yamamoto, .et al. Mycoplasma pneumoniae protects infected epithelial cells from hydrogen peroxide坼induced cell detachment, Cell Microbiol, 2019, 2019 PMID: 30702185
  • D. Bosc, .et al. A new quinoline-based chemical probe inhibits the autophagy-related cysteine protease ATG4B, Sci Rep, 2018, 8: 11653 PMID: 30076329
  • Tsukamoto H, .et al. Lipopolysaccharide (LPS)-binding protein stimulates CD14-dependent Toll-like receptor 4 internalization and LPS-induced TBK1-IKK?-IRF3 axis activation, J Biol Chem, 2018, Jun 29;293(26):10186-10201 PMID: 29760187
  • Hiroshi Kuribayashi, .et al. Roles of Nmnat1 in the survival of retinal progenitors through the regulation of pro-apoptotic gene expression via histone acetylation, Cell Death Dis, 2018, Sep; 9(9): 891 PMID: 30166529
  • Matsuo J, .et al. Activation of caspase-3 during Chlamydia trachomatis-induced apoptosis at a late stage, Can J Microbiol, 2018, Oct 18:1-9 PMID: 30336068
  • Orly Ravid, .et al. Blood-Brain Barrier Cellular Responses Toward Organophosphates: Natural Compensatory Processes and Exogenous Interventions to Rescue Barrier Properties, Front Cell Neurosci, 2018, 12: 359 PMID: 30459557
  • Im E, .et al. Luteolin induces caspase-dependent apoptosis via inhibiting the AKT/osteopontin pathway in human hepatocellular carcinoma SK-Hep-1 cells, Life Sci, 2018, Sep 15;209:259-266 PMID: 30107166
  • Szalai P, .et al. Nonlinear relationship between ER Ca2+ depletion versus induction of the unfolded protein response, autophagy inhibition, and cell death, Cell Calcium, 2018, Dec;76:48-61 PMID: 30261424
  • Im E, .et al. Dihydroartemisinin induced caspase-dependent apoptosis through inhibiting the specificity protein 1 pathway in hepatocellular carcinoma SK-Hep-1 cells, Life Sci, 2018, Jan 1;192:286-292 PMID: 29128513
  • Iriyama N, .et al. The cyclin-dependent kinase 4/6 inhibitor, abemaciclib, exerts dose-dependent cytostatic and cytocidal effects and induces autophagy in multiple myeloma cells, Leuk Lymphoma, 2018, Jun;59(6):1439-1450 PMID: 28918692
  • Birte Plitzko, .et al. The natural product mensacarcin induces mitochondrial toxicity and apoptosis in melanoma cells, J Biol Chem, 2017, Dec 22; 292(51): 21102每21116 PMID: 29074620
  • Akashi E, .et al. Effects of galectin-9 on apoptosis, cell cycle and autophagy in human esophageal adenocarcinoma cells, Oncol Rep, 2017, Jul;38(1):506-514 PMID: 28586026

Chemical Information

目录号 A12373
Mechanism of action Inhibitor
分子量 467.49
化学分子式 C22H30FN3O7
Solubility DMSO
纯度 >98%
储存方式 at -20°C 2 years
CAS No. 187389-52-2
Synonyms N/A
SMILES code C[C@@H](C(=O)N[C@@H](CC(=O)OC)C(=O)CF)NC(=O)[C@H](C(C)C)NC(=O)OCC1=CC=CC=C1
化学名称 Benzyloxycarbonyl-Val-Ala-Asp(OMe)-?fluoromethylketone

生物活性

Description
Z-VAD-FMK is a cell-permeable, irreversible pan-caspase inhibitor. Inhibits caspase processing and apoptosis induction in tumor cells in vitro (IC50 = 0.0015 - 5.8 mM). Active in vivo.
Targets
Pan-caspase (THP.1, Jurkat T-cells)

溶解性

Solubility (25°C) * In vitro DMSO 93 mg/mL (198 mM)
Water <1 mg/mL (<1 mM)
Ethanol 24 mg/mL heating (51 mM)
In vivo DMF 84 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 21.39 mL 106.95 mL 213.91mL
0.5 mM 4.28 mL 21.39 mL 42.78 mL
1 mM 2.14 mL 10.7 mL 21.39 mL
5 mM 0.43 mL 2.14 mL 4.28 mL

*The above data is based on the productmolecular weight 467.49. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

View Related Products By Research Topics

Cat. No.

Product NameSolubility(mg/mL)
WaterDMSOEthanol
A10255ABT-737<1 mg/mL163 mg/mL<1 mg/mL
A10022ABT-263 (Navitoclax)<1 mg/mL195 mg/mL<1 mg/mL
A10665Obatoclax mesylate (GX15-070)<1 mg/mL83 mg/mL<1 mg/mL
A10955TW-37<1 mg/mL115 mg/mL4 mg/mL
A10984VX-765<1 mg/mL102 mg/mL102 mg/mL
A11090PAC-1<1 mg/mL78 mg/mL16 mg/mL
A10491JNJ 26854165<1 mg/mL66 mg/mL2 mg/mL
A11931RITA (NSC 652287)<1 mg/mL115 mg/mL4 mg/mL
A10522Lenalidomide (CC-5013)<1 mg/mL52 mg/mL<1 mg/mL
A10743Pomalidomide (CC-4047)<1 mg/mL55 mg/mL<1 mg/mL
A11163AT-406<1 mg/mL112 mg/mL112 mg/mL
A11002YM15589 mg/mL55 mg/mL6 mg/mL
A10935Tipifarnib (Zarnestra)<1 mg/mL83 mg/mL<1 mg/mL
A10657Nutlin-3<1 mg/mL116 mg/mL116 mg/mL

Ordering online

To place an order online, simply browse to the product you are interested in and click on the 'Add to Cart' button. To complete this process, you will need to confirm the size and quantity of the products that you require.

To complete an order you will need to register using our simple online registration process. We do not share your contact details with any third parties.

When you are ready to check out simply enter your PO number to complete the ordering process. Please ensure that you send us a copy of your PO by fax or email afterwards.  We will then liaise with you or your purchasing department to confirm the order.

Found your products but not ready to order?

Why not use our WishList feature to store lists of products? This convenient feature allows you to manage lists, append notes to products and share lists with co-workers or colleagues.

Ordering offline

You can email or fax us your purchase order and we will place the order for you. You can also phone us to place the order.  Our contact details are:

We require the following information to process your order:
  • The catalog number for each product. 
  • Your email address or fax number. 
  • Your name and telephone number. 
  • Shipping address and billing address.
  • Purchase order numbers.

产品标签

其他人对该产品使用了下列标签:

使用空格分隔标签。使用单引号(')标注词组。

Similar product(s)


Keywords:购买 Z-VAD-FMK | Z-VAD-FMK 供应商 | 订购 Z-VAD-FMK | Z-VAD-FMK 价格 | Z-VAD-FMK 生产商 | 订单 Z-VAD-FMK | Z-VAD-FMK 代理商 | 购买 187389-52-2| 187389-52-2 供应商 | 订购 187389-52-2 | 187389-52-2 价格 | 187389-52-2 生产商 | 订单 187389-52-2 | 187389-52-2 代理商|buy Z-VAD-FMK | Z-VAD-FMK Supplier | purchase Z-VAD-FMK | Z-VAD-FMK cost | Z-VAD-FMK manufacturer | order Z-VAD-FMK | Z-VAD-FMK distributor | buy 187389-52-2| 187389-52-2 Supplier | purchase 187389-52-2 | 187389-52-2 cost | 187389-52-2 manufacturer | order 187389-52-2 | 187389-52-2 distributor