Afatinib dimaleate

目录号: A14985

EGFR inhibitor

Afatinib dimaleate

Afatinib dimaleate Chemical Structure

CAS NO. 850140-73-7

Afatinib is an irreversible EGFR/HER2 inhibitor with an IC50 of 14 nM for in vitro potency against HER2.

库存: 现货

规格 价格 数量
25 mg
¥ 750.00
50 mg
¥ 1,100.00
100 mg
¥ 1,500.00
Warning 产品仅用于科学研究,不针对患者销售,望谅解.

详情

Afatinib is an irreversible EGFR/HER2 inhibitor with an IC50 of 14 nM for in vitro potency against HER2.
Targets
EGFR (L858R) EGFR (wt) EGFR (L858R/T790M) HER2
0.4 nM0.5 nM10 nM14 nM
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 13.93 mL 69.63 mL 139.26 mL
0.5 mM 2.79 mL 13.93 mL 27.85 mL
1 mM 1.39 mL 6.96 mL 13.93 mL
5 mM 0.28 mL 1.39 mL 2.79 mL

*The above data is based on the productmolecular weight 718.08. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Technical Details

目录号 A14985
MECHANISM OF ACTION Inhibitor
M. Wt 718.08
Formula C32H33ClFN5O11
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 850140-73-7
Synonyms BIBW 2992MA2, BIBW-2992, BIBW2992, BIBW 2992, Afatinib
SMILES CN(C)CC=CC(=O)NC1=C(C=C2C(=C1)C(=NC=N2)NC3=CC(=C(C=C3)F)Cl)OC4CCOC4.C(=CC(=O)O)C(=O)O.C(=CC(=O)O)C(=O)O

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