Afatinib dimaleate

Name: Afatinib dimaleate
SKU: A14985

目录号: A14985

EGFR 抑制剂

Afatinib dimaleate Chemical Structure

CAS NO. 850140-73-7

Afatinib dimaleate是一种不可逆的EGFR/HER2抑制剂，对于HER2的体外药效IC50为14 nM。

库存：现货

规格	价格	数量
25 mg	￥ 750.00
50 mg	￥ 1,100.00
100 mg	￥ 1,500.00

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生物活性

Afatinib dimaleate是一种不可逆的EGFR/HER2抑制剂，对于HER2的体外药效IC50为14 nM。

靶点信息

EGFR (L858R)	EGFR (wt)	EGFR (L858R/T790M)	HER2
0.4 nM	0.5 nM	10 nM	14 nM

溶解度 *

In vitro (25°C)	DMSO	87 mg/mL (121.3 mM)
	Water	Insoluble
	Ethanol	Insoluble
In vivo	5% DMSO+30% PEG 300+ddH2O	26 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	13.93 mL	69.63 mL	139.26 mL
0.5 mM	2.79 mL	13.93 mL	27.85 mL
1 mM	1.39 mL	6.96 mL	13.93 mL
5 mM	0.28 mL	1.39 mL	2.79 mL

*The above data is based on the productmolecular weight 718.08. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

化学数据

目录号	A14985
作用机制	Inhibitor (抑制剂)
M. Wt	718.08
Formula	C32H33ClFN5O11
Purity	>99%
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
CAS No.	850140-73-7
Synonyms	BIBW 2992MA2, BIBW-2992, BIBW2992, BIBW 2992, Afatinib
SMILES	CN(C)CC=CC(=O)NC1=C(C=C2C(=C1)C(=NC=N2)NC3=CC(=C(C=C3)F)Cl)OC4CCOC4.C(=CC(=O)O)C(=O)O.C(=CC(=O)O)C(=O)O