Afatinib dimaleate

Name: Afatinib dimaleate
SKU: A14985
Price: 175 CNY
Rating: 5 (288 reviews)

目录号: A14985

EGFR 抑制剂

Afatinib 是一种不可逆的 EGFR/HER2 抑制剂，其对 HER2 的体外活性的 IC50 为 14 nM。

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Grouped product items
规格	价格	库存
5mg	¥175.00	现货
10mg	¥315.00	现货
25mg	¥490.00	现货
50mg	¥700.00	现货
100mg	¥945.00	现货
200mg	¥1,330.00	现货
500mg	¥2,240.00	现货
1g	¥3,395.00	现货
*10mM 1mL in DMSO**	¥385.00	现货
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重要通知：仅供研究使用。我们不向患者销售。

Data Sheet

SDS

Other Forms of Afatinib dimaleate

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生物活性

Discription

Afatinib is an irreversible EGFR/HER2 inhibitor with an IC50 of 14 nM for in vitro potency against HER2.

Targets

Target	Value

产品信息

目录号	A14985
分子式	C32H33ClFN5O11
分子量	718.08
CAS号	850140-73-7
SMILES	CN(C)CC=CC(=O)NC1=C(C=C2C(=C1)C(=NC=N2)NC3=CC(=C(C=C3)F)Cl)OC4CCOC4.C(=CC(=O)O)C(=O)O.C(=CC(=O)O)C(=O)O
其他名称	BIBW 2992MA2, BIBW-2992, BIBW2992, BIBW 2992, Afatinib
储存条件	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

溶解性数据

In vitro (25°C)	DMSO	87 mg/mL (121.3 mM)
	Water	Insoluble
	Ethanol	Insoluble
In vivo	5% DMSO+30% PEG 300+ddH2O	26 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	13.93 mL	69.63 mL	139.26 mL
0.5 mM	2.79 mL	13.93 mL	27.85 mL
1 mM	1.39 mL	6.96 mL	13.93 mL
5 mM	0.28 mL	1.39 mL	2.79 mL

Useful Calculator

This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

Calculate Reset

* Please check COA/MSDS for correct molecular weight.

Calculate the dilution required to prepare a stock solution.
This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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