Afatinib
Afatinib（BIBW 2992）是一种不可逆的EGFR家族抑制剂，其IC50分别为0.5 nM、0.4 nM、10 nM和14 nM，针对EGFRwt、EGFRL858R、EGFRL858R/T790M和HER2。
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生物活性
| Discription | Afatinib (BIBW 2992) is an irreversible EGFR family inhibitor with IC50s of 0.5 nM, 0.4 nM, 10 nM and 14 nM for EGFRwt, EGFRL858R, EGFRL858R/T790M and HER2, respectively. | ||
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产品信息
| 目录号 | A18014 |
|---|---|
| 分子式 | C24H25ClFN5O3 |
| 分子量 | 485.94 |
| CAS号 | 850140-72-6 |
| SMILES | O=C(NC1=CC2=C(NC3=CC=C(F)C(Cl)=C3)N=CN=C2C=C1O[C@@H]4COCC4)/C=C/CN(C)C |
| 其他名称 | BIBW 2992, BIBW-2992, BIBW2992 |
| 储存条件 | Store lyophilized at -20ºC, keep desiccated. |
溶解性数据
| In vitro (25°C) | DMSO | 90 mg/mL (185.21 mM) | |
| Water | Insoluble | ||
| Ethanol | 14 mg/mL (28.8 mM) | ||
| In vivo | 2% DMSO+30% PEG 300+5% Tween 80+ddH2O | 9 mg/mL | |
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* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
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Preparing Stock Solutions
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 20.58 mL | 102.89 mL | 205.79 mL |
| 0.5 mM | 4.12 mL | 20.58 mL | 41.16 mL |
| 1 mM | 2.06 mL | 10.29 mL | 20.58 mL |
| 5 mM | 0.41 mL | 2.06 mL | 4.12 mL |
Useful Calculator
Calculate the dilution required to prepare a stock solution. This equation is commonly abbreviated as: C1V1 = C2V2
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