Calcium-Sensing Receptor

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  1. NPS-2143 (SB-262470)

    Catalog No. A11140
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    CaSR antagonist
    NPS-2143 is a selective Ca2+-sensing receptor antagonist, shown to block increases in cytoplasmic Ca2+ concentrations elicited by human Ca2+ receptors expressed in HEK293 cells with an IC50 of 43 nM. 了解更多
  2. AMG-073 HCl (Cinacalcet HCl)

    Catalog No. A10219
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    CaSR activator
    AMG-073 HCl (Cinacalcet HCl) represents a new class of compounds for the treatment of hyperparathyroidism known as calcimimetics, which reduce parathyroid hormone (PTH) synthesis and secretion by increasing the sensitivity of the parathyroid calcium-sensing receptor (CaR) to extracellular calcium. 了解更多
  3. Strontium ranelate (Protelos)

    Catalog No. A11681
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    CaSR agonist
    Strontium ranelate is an antiosteoporotic agent which both increases bone formation and reduces bone resorption, resulting in a rebalance of bone turnover in favor of bone formation. This is similar to the effects of choline stabilized orthosilicic acid. 了解更多
  4. AMG 073 (Cinacalcet)

    Catalog No. A11314
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    CaSR activator
    AMG-073 (Cinacalcet) represents a new class of compounds for the treatment of hyperparathyroidism. 了解更多
  5. Evocalcet

    Catalog No. A17003
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    CaSR agonist
    Evocalcet是一种钙敏感受体激动剂。 钙敏感受体(CaSR)是一种C类G蛋白偶联受体,可检测细胞外钙离子水平。 了解更多

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