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Protein Synthesis 抑制剂
环己酰胺（又称为放线菌酮）被用作一种选择性抗生素。它通过与80S核糖体结合，抑制腐生真菌真核生物的蛋白质合成（依赖DNA的RNA），而对皮肤癣菌和系统性真菌无效。- Xiao-Yi Zhang, .et al. , Free Radic Biol Med, 2025, Aug 25:S0891-5849(25)00940-2 PMID: 40865778
- Wan-Cheng Liu, .et al. , Nat Commun, 2025, Jun 3;16(1):5154 PMID: 40461504
- Xingmei Shu, .et al. , Chin Med J (Engl), 2025, May 23 PMID: 40405358
- Jing Wang, .et al. , Mol Cell, 2025, May 15;85(10):1999-2016.e11 PMID: 40328247
- Yang Liao, .et al. , Cell Signal, 2025, Jul:131:111735 PMID: 40081551
- Xiangdong Qiu, .et al. , Cardiovascular Toxicology, 2025, 25: 427-440
- Tianfeng Huang, .et al. , Mol Neurobiol, 2024, Sep 13 PMID: 39271624
- Han Xiao, .et al. , JPA, 2023, Apr 19
- Shuanghui Lu, .et al. , Chem Biol Interact, 2022, Dec 1;368:110219 PMID: 36243147
- Ke Chen, .et al. , Cancer Commun (Lond), 2021, Apr; 41(4): 316-332 PMID: 33591636
- Zhiyuan Qin, .et al. , Cancers (Basel), 2021, Feb 4;13(4):618 PMID: 33557163
- Hua Xu, .et al. , Cancers (Basel), 2020, Apr; 12(4): 831 PMID: 32235588
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DNA and RNA synthesis 抑制剂
氟尿嘧啶（Adrucil）是一种自杀抑制剂，其作用机制是通过不可逆地抑制胸苷酸合成酶来发挥作用。- Majid Momeny, .et al. , EMBO Mol Med, 2024, Jun 17 PMID: 38886591
- Adi Jacob Berger, .et al. , Nat Cancer, 2021, 2, 1055-1070 PMID: 35121883
