INCB018424 (Ruxolitinib)

目录号: A11041

JAK1/2 抑制剂

INCB018424 (Ruxolitinib) Chemical Structure

CAS NO. 941678-49-5

INCB018424 (Ruxolitinib)是有效和选择性的Janus相关激酶JAK1/2抑制剂,对JAK1,JAK2和JAK3的IC50分别为2.7、4.5和332 nM。

库存: 现货

规格 价格 数量
5 mg
¥ 600.00
10 mg
¥ 700.00
25 mg
¥ 900.00
100 mg
¥ 1,600.00
10mM * 1mL in DMSO
¥ 600.00
Warning 产品仅用于科学研究,不针对患者销售,望谅解.

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INCB018424 (Ruxolitinib)是有效和选择性的Janus相关激酶JAK1/2抑制剂,对JAK1,JAK2和JAK3的IC50分别为2.7、4.5和332 nM。
In vitro DMSO 61 mg/mL (199.1 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 32.64 mL 163.19 mL 326.37 mL
0.5 mM 6.53 mL 32.64 mL 65.27 mL
1 mM 3.26 mL 16.32 mL 32.64 mL
5 mM 0.65 mL 3.26 mL 6.53 mL

*The above data is based on the productmolecular weight 306.4 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

目录号 A11041
MECHANISM OF ACTION Inhibitor
M. Wt 306.4
Formula C17H18N6
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 941678-49-5
Synonyms Ruxolitinib, INCB18424
SMILES C1CCC(C1)[C@@H](CC#N)N2C=C(C=N2)C3=C4C=CNC4=NC=N3

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