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INCB018424 (Ruxolitinib)

JAK1/2 抑制剂

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产品目录号: A11041

库存状态:中国现货中国现货

产品名 目录号 价格 数量
INCB018424 5mg A11041-5
¥ 600.00
INCB018424 10mg A11041-10
¥ 700.00
INCB018424 25mg A11041-25
¥ 900.00
INCB018424 100mg A11041-100
¥ 1,600.00
INCB018424 (Ruxolitinib) 10mM * 1mL in DMSO A11041-10mM-D
¥ 600.00

产品仅用于研究,不针对患者销售,望谅解.

产品简介

INCB018424 is a potent and selective inhibitor of Janus-associated kinase (JAK) 1 and 2, with IC50 to be 2.7, 4.5 and 332 nM for JAK1, JAK2 and JAK3 respectively;

INCB018424 (Ruxolitinib)

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顾客使用 Adooq 产品发表的高质量科研文献
Adooq 顾客使用 INCB018424 (Ruxolitinib) 发表的文献 (3)
  • Brittany M. Duggan, .et al. Tyrosine kinase inhibitors of Ripk2 attenuate bacterial cell wall-mediated lipolysis, inflammation and dysglycemia, Sci Rep, 2017, 7: 1578 PMID: 28484277
  • Fujita KI, .et al. Involvement of the Transporters P-Glycoprotein and Breast Cancer Resistance Protein in Dermal Distribution of the Multikinase Inhibitor Regorafenib and Its Active Metabolites, J Pharm Sci, 2017, Sep;106(9):2632-2641 PMID: 28479358
  • Kagoya Y, .et al. JAK2V617F+ myeloproliferative neoplasm clones evoke paracrine DNA damage to adjacent normal cells through secretion of lipocalin-2., Blood., 2014, Nov 6;124(19):2996-3006 PMID: 25217696

Chemical Information

目录号 A11041
Mechanism of action Inhibitor
分子量 306.4
化学分子式 C17H18N6
Solubility DMSO
纯度 >98%
储存方式 at -20°C 2 years
CAS No. 941678-49-5
Synonyms Ruxolitinib, INCB18424
SMILES code C1CCC(C1)[C@@H](CC#N)N2C=C(C=N2)C3=C4C=CNC4=NC=N3
化学名称 (R)-3-(4-(7H-Pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl)-3-cyclopentylpropanenitrile

生物活性

Description
INCB018424 is a potent and selective inhibitor of Janus-associated kinase (JAK) 1 and 2, with IC50 to be 2.7, 4.5 and 332 nM for JAK1, JAK2 and JAK3 respectively;

溶解性

Solubility (25°C)* In vitro DMSO 61 mg/mL (199.1 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 32.64 mL 163.19 mL 326.37mL
0.5 mM 6.53 mL 32.64 mL 65.27 mL
1 mM 3.26 mL 16.32 mL 32.64 mL
5 mM 0.65 mL 3.26 mL 6.53 mL

*The above data is based on the productmolecular weight 306.4 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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